血清胃蛋白酶原Ⅰ、Ⅱ在老年慢性胃炎患者筛查中的意义

Screening significance of the serum pepsinogenⅠand Ⅱin elderly patients with chronic gastritis

目的：探讨血清胃蛋白酶原（PG）Ⅰ、Ⅱ对老年慢性胃炎的筛查意义。方法：选择经胃镜和病理学检查诊断为慢性胃炎的患者98例,其中老年组（≥70岁）52例,中青年组（20~60岁）46例,分别对2组患者进行血清PGⅠ、PGⅡ检测,计算PGR（PGⅠ/PGⅡ）值。结果：2组中慢性萎缩性胃炎患者的PGⅠ水平和PGR均明显低于慢性非萎缩性胃炎患者（P〈0.01）;老年组患者中慢性萎缩性胃炎患者的PGⅠ水平和PGR均显著低于中青年组（P〈0.01）;老年组慢性萎缩性患者的ROC曲线图中,PGⅠ的临界值为98.06μg/L,灵敏度和特异度分别为0.812和0.858;PGR的临界值为6.68,灵敏度和特异度分别为0.758和0.810。结论：检测血清PGⅠ、Ⅱ对于筛查老年慢性萎缩性胃炎患者具有重要意义,需要进一步确定其参考范围。

Objective： To explore the screening significance of serum pepsinogenⅠ and Ⅱ（ PG Ⅰ and PG Ⅱ） in elderly patients with chronic gastritis. Methods： Ninety-eight elderly patients with chronic gastritis diagnosed by gastroscopy and pathology were divided into the elderly group（ 52 cases,over 70 years old） and young and middle-aged group（ 46 cases,20 to 60 years old）. The serum levels of PG Ⅰ and PG Ⅱ in two groups were measured,and the value of PGR（ PGⅠ / PGⅡ） was calculated. Results： The levels of the PGⅠand PGR in patients with chronic atrophic gastritis were significantly lower than those in patients with chronic non-atrophic gastritis in two groups（ P〈0. 01）. The levels of the PGⅠand PGR in the elderly group were significantly lower than those in young and middleaged group（ P〈0. 01）. The ROC curve of the chronic atrophic patients in elderly group showed that the critical value of PG Ⅰ,sensitivity and specificity were 98. 06 μg / L,0. 812 and 0. 858,respectively,and the critical value of PGR,sensitivity and specificity were 6. 68 μg / L,0. 758 and 0. 810,respectively. Conclusions： The detection of serum pepsinogen Ⅰ and Ⅱ has important clinic significance in screening elderly patients with chronic atrophic gastritis,which need to further define its reference range.