普罗帕酮治疗小儿川崎病合并心律失常患儿的临床疗效

Analyze the Clinical Effect of Propafenone in Children with Kawasaki Disease Complicated with Arrhythmia

目的探究应用普罗帕酮治疗小儿川崎病合并心律失常患儿的临床疗效。方法选择2015年7月至2016年8月接受治疗的小儿川崎病合并心律失常疾病的患儿60例作为研究对象,按照入院时间先后依次编号01至60,以双号为对照组,单号为试验组,各30例。对照组接受常规药物治疗,试验组给予普罗帕酮治疗,比较两组治疗后的临床疗效以及不良反应发生情况。结果试验组总有效率(96.7%)明显高于对照组(73.3%);对照组的心脏指数(3.61±0.12)L/(min·m2)以及左心室射血分数(72.22±2.12)%显著低于试验组的心脏指数(3.81±0.36)L/(min·m2)以及左心室射血分数(76.68±3.46)%,差异均有统计学意义(P<0.05)。结论应用普罗帕酮治疗小儿川崎病合并心律失常,效果理想,安全性高,改善患儿的心肌功能。

Objective To explore the clinical effect of propafenone in treating children with Kawasaki disease complicated with arrhythmia. Methods 60 cases of children with Kawasaki disease complicated with arrhythmia were selected as clinical research subjects from July 2015 to August 2016, 60 cases of patients were treated in our hospital according to the time of admission,the patients with double number were as the control group, the patients with single patient were as the observation group. 30 patients in the control group were received conventional drug therapy, 30 patients in the observation group were given propafenone for treatment, compared with all patients after treatment of clinical efficacy and adverse reaction occurred. Results The total effective rate（96.7%） in the observation group was significantly higher than that in the control group（73.3%）. The cardiac index（3.61±0.12） L/（min·m2） and left ventricular（72.22±2.12）% in the control group were significantly lower than those in the observation group of（3.81±0.36） L/（min·m2） and the ejection fraction of left ventricle（76.68±3.46）%, the differences were statistically significant（P0.05）. Conclusion The application of propafenone in children with Kawasaki disease with arrhythmia, the ideal, safe, improve myocardial function in children, it is worthy of widespread clinical application.