薄冰凉雾剂治疗视频相关性干眼症的临床观察

Clinical Observation of Ice Cold Spray Treatment on Video Correlated Dry Eye Syndrome

目的观察薄冰凉雾剂治疗视频相关性干眼症的临床疗效。方法将视频相关性干眼症患者72例(144只眼)随机分为治疗组和对照组,各36例(72只眼)。治疗组采取薄冰凉雾剂治疗,对照组采用灭菌注射用水治疗,两组均每2日治疗1次,疗程为2周。结果治疗组治疗后主观症状及客观指标评分较治疗前,均差异有统计学意义(P<0.05);对照组治疗前后在眼干涩、烧灼感、泪膜破裂时间评分方面,差异有统计学意义(P<0.05),在异物感、畏光、视疲劳、泪液分泌量、角膜染色评分方面,差异无统计学意义(P>0.05)。治疗组总有效率为80.56%,对照组总有效率为22.22%,两组比较,差异有统计学意义(P<0.05)。结论局部雾化对干眼症是可行的治疗,薄冰凉雾剂治疗视频相关性干眼症疗效较好。

Objective： To observe the clinical effect of ice cold spray treatment on video correlated dry eye syn- drome. Methods： 72 cases （144 eyes） of patients with video correlated dry eye syndrome in our department were randomly divided into two groups： Ice cold spray group [treatment group of 36 patients （72 eyes）] and sterile water for injection group[contrast group of 36 patients（72 eyes）]. The treatment was applied one time per two days and the treatment course was 2 weeks. The subjective symptoms （dryness,foreign body sensation,burning sensation, photophobia, visual fatigue） and objective indexes （tear break-up time, tear secretion test, corneal staining） were observed and recorded respectively before treatment and 2 weeks after the treatment, and the data of the two groups were analyzed statistically. Using software SPSS 17,with P=0.05 as the test standard,the comparison between the two groups used the paired sample t test. Results： Before and after treatment,the difference of subjective symptoms and objective indexes in the treatment group were statistically significant （P〈 0.05）,the score difference in contrast group before and after treatment in eye dryness, burning sensation, tear break-up time was statistically significant （P〈 0.05）,the score difference in the sense of foreign body,photophobia,visual fatigue,tear secretion ,corneal staining had no statistical significance （P〉 0.05 ）. The total effective rate of the treatment group was 80.56%, and the total effective rate of the contrast group was 22.22%. The difference was statistically significant（P 〈 0.05）. Conclusion： Local aerosol is feasible in treatment of dry eye,ice cold spray is effective in treatment of dry eye.