生长分化因子-15在垂体腺瘤中的表达及意义

Expression and significance of growth differentiation factor-15 in pituitary adenomas

目的探讨生长分化因子(GDF)-15在垂体腺瘤中的表达及意义。方法选择100例垂体腺瘤患者组织标本,根据是否具有侵袭性分为侵袭性垂体腺瘤63例和非垂体腺瘤37例,并选择同期在本院接受体检的健康人员50例作为对照组。比较各组受试者GDF-15的表达,并分析GDF-15和垂体腺瘤侵袭性的相关性。结果泌乳素垂体腺瘤与生长激素垂体腺瘤患者GDF-15均显著高于无功能性垂体腺瘤患者(P<0.50);侵袭性垂体腺瘤患者GDF-15水平显著高于非侵袭性组及对照组(P<0.05);GDF-15和侵袭性垂体腺瘤呈正相关(r=0.328,P=0.001)。结论在垂体腺瘤患者中,GDF-15的表达较高,且GDF-15水平和垂体瘤侵袭性存在相关性。

Objective To explore expression and significance of growth differentiation factor （GDF） -15 in pituitary adenomas. Methods A total of 100 tissue samples of patients with pituitary adenomas were selected and divided into invasive pituitary adenomas group （n = 63 ） and non-pituita- ry adenomas group （n = 37） according to aggressive condition, and 50 healthy people were selected as control group. The expression of GDF-15 was compared among the three groups, and the correlation between GDF-15 and the invasiveness of pituitary adenomas was analyzed. Results The level of GDF-15 in patients with prolactin secreting pituitary adenomas and growth hormone adenomas was significantly higher than that of patients with non-functional pituitary adenomas （ P 〈 0.05 ）. The level of GDF-15 in the invasive pituitary adenomas group was significantly higher than the non-invasive group and the control group （ P 〈 0.05 ）. The correlation analysis showed that there was a positive correla- tion between GDF-15 and invasive pituitary adenomas （r = 0. 328, P = 0.001 ）. Conclusion In patients with pituitary adenomas, the expression of GDF-15 is higher, and there is a correlation between the GDF-15 level and the invasiveness of pituitary adenomas.