喜炎平雾化吸入联合阿昔洛韦对小儿疱疹性咽峡炎的疗效及对炎症因子的影响

Efficacy of Xiyanping inhalation combined with acyclovir in treatment of children with herpangina and its influence on inflammatory factors

目的分析喜炎平雾化吸入联合阿昔洛韦对小儿疱疹性咽峡炎的疗效及对炎症因子的影响。方法选取90例小儿疱疹性咽峡炎患者,随机分为观察组和对照组。观察组采用喜炎平雾化吸入联合阿昔洛韦治疗,对照组采用喜炎平联合阿昔洛韦静脉滴注治疗,比较2组患者的疗效、临床体征消失时间、住院时间、治疗前后炎症因子变化情况及不良反应。结果观察组治疗总有效率显著高于对照组(P<0.05);观察组发热、疱疹、流涎临床体征的消失时间和住院时间显著短于对照组(P<0.05);2组患者治疗后炎症因子IL-6、TNF-α、IL-2及IL-10含量比较有显著差异(P<0.05);2组患者不良反应比较差异无统计学意义(P>0.05)。结论喜炎平雾化吸入联合阿昔洛韦对小儿疱疹性咽峡炎的疗效显著。

Objective To analyze the efficacy of Xiyanping inhalation combined with acyclovir in treatment of children with herpangina and its influence on inflammatory factors. Methods A total of 90 children with herpangina were randomly divided into observation group and control group. The observation group was treated with Xiyanping inhalation combined with aeyclovir, while control group was given intravenous dripping disappeared time, hospitalization time, the c of Xiyanping and acyclovir. The hange of inflammatory factors and effect, clinical signs adverse reactions before and after treatment were compared. Results The total effective rate of the observation group was significantly higher than the control group （P 〈 0.05 ）. The disappearance time of the fever, herpes, salivation clinical signs and hospitalization time in the observation group were significantly shorter than the control group （P 〈 0.05 ）. After treatment, there were significant differences in inflammatory cytokines such as IL-6, TNF-α, IL-2 and IL-10 between two groups （P 〈 0.05 ）. There was no significant difference between the two groups in incidence rate of adverse reactions （ P 〉 0.05 ）. Conclusion Xiyanping inhalation combined with acyclovir is effective in treatment of children with herpangina.