健康管理对感染高危型HPV妇女健康行为的影响

Effect of health management on health behavior of women with high-risk HPV infection

目的探讨健康管理模式对感染高危型HPV妇女健康行为的影响。方法选择2012年1月-2013年12月石碣镇完成宫颈癌筛查的户籍妇女中高危型HPV检测阳性者200例为研究对象,按照随机性的原则进行分组,分为实验组与对照组,各100例。实验组采用健康管理干预措施,并定期随访复查;对照组定期随访复查。实施健康管理干预1年后对两组HPV感染转阴率、病毒负荷量RLU/CO比值、HPV感染相关知信行变化情况进行评价。结果干预后1年,实验组的高危型HPV感染转阴率为32.0%,对照组的高危型HPV感染转阴率为15.0%,实验组明显高于对照组,差异有统计学意义(χ~2=12.47,P<0.05)。两组妇女的病毒负荷量RLU/CO比值比较,实验组明显低于对照组,差异有统计学意义(t=16.68,P<0.05)。干预前,两组妇女的HPV感染知信行各维度得分比较,差异无统计学意义(均P>0.05)。干预后1年,实验组的HPV感染相关知信行各维度得分均明显高于对照组,差异有统计学意义(均P<0.05)。结论对高危型HPV感染妇女人群实施健康管理,能改善高危型HPV感染妇女人群的不良行为方式,并进一步提高其HPV感染的相关知信行,从而有效地提高了HPV感染的转阴率,降低其病毒负荷量RLU/CO比值,达到降低宫颈癌的发病率,提高妇女的健康水平和生活质量的目的。

Objective To explore the effect of health management mode on health behavior of women with high-risk papillomavirus （ HPV ） infection. Methods We selected 200 high-risk HPV-positive women as the research objects among the female permanent residents with cervical cancer screening in Shijie Town from January 2012 to December 2013. According to the principle of random grouping, the 200 women were divided into the experiment group and the control group （ each n= 100）. The experiment group received health management interventions, regular follow-up and reexamination, while the control group only accepted regular follow-up and reexaminaiton. After implementing 1-year health intervention, the changes in the negative conversion rate of high -risk HPV infection, the virus load RLU/CO ratio and HPV-related knowledge, attitude and practice （KAP） were evaluated and compared between the two groups. Results After 1-year health intervention, the negative conversion rate of high-risk HPV infection was significantly higher in the experiment group than in the control group （ 32.0% vs. 15.0% ） , showing a statistically significant difference （χ^2= 12.47, P〈0.05）. The virus load RLU/CO ratio was significantly lower in the experiment group than in the control group, with a statistically significant difference （ t = 16.68, P〈0.05 ）. Before the intervention, no statistically significant difference was observed in the score of each dimension of HPV-related KAP between the two groups （ all P〉0.05 ）. After the 1- year intervention, the score of each dimension of HPV-related KAP was significantly higher in the experimental group than in the control group, with statistically significant differences （all P〈0.05）. Conclusion Implementing health management among women with high-risk HPV infection can ameliorate their unhealthy behavior and further improve their HPV-related KAP so as to effectively increase the negative conversion rate of high-risk HPV infection, decline the virus load RLU/CO ratio, decrease the incidence of cervical cancer and improve their health level and quality of life.