体检人群心踝血管指数与心血管危险因素的相关性研究

Correlation between the cardio-ankle vascular index and cardiovascular risk factors in health examination population

目的:探讨心踝血管指数(cardio-ankle vascular index,CAVI)与心血管危险因素的相关性,为早期干预提供依据。方法:对5458例受检者进行CAVI、腰围、体质量指数、血压、尿素氮、肌酐、空腹血糖、血浆总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇的检测;根据CAVI正常与否将研究对象分为CAVI异常组(CAVI≥9.0 m/s)和CAVI正常组(CAVI<9.0 m/s),用t检验、卡方检验比较组间临床和生化资料,运用logistic回归分析CAVI的相关影响因素。结果:CAVI异常组年龄[(65.24±10.28)岁]、男性比例(71.68%)、腰围[(84.39±7.51)cm]、空腹血糖[(6.14±1.81)mmol/L]、糖尿病比例(22.82%)、尿素氮[(5.84±1.73)mmol/L]、肌酐[(75.16±22.35)mmol/L]、高血压比例(65.66%)均高于CAVI正常组,且差异有统计学意义(P<0.05)。多元logistic回归显示年龄、性别、空腹血糖、肌酐、血压是CAVI的独立影响因素(P<0.05)。结论:本研究显示增龄、高血糖、高血压和肌酐升高与CAVI显著相关,提示加强老年人动脉硬化筛查工作,有效控制血糖、血压、肌酐有利于延缓动脉硬化进展。

Objective：To investigate the correlation between the cardio-ankle vascular index（CAVI）and cardiovascular risk factors in health examination population and to provide the proof for early intervention. Methods：Totally 5 458 cases for health examination from January to August in 2015 were enrolled in the study and divided into abnormal group（CAVI≥9.0 m/s）and normal group（CAVI9.0m/s）. The clinical data and biochemical data including blood pressure,CAVI,waist circumference,body mass index,total cholesterol,triglycerid,high density lipoprotein cholesterol,low density lipoprotein cholesterol,fasting blood glucose,urea nitrogen,and creatinine were collected and compared in two groups. Logistic regression analysis was conducted to predict the CAVI related factors. Results：The average age,male ratio,waist circumference,fasting blood glucose,diabetes proportion,urea nitrogen and the creatinine,and the proportion of high blood pressure were significantly higher in CAVI abnormal group. Multivariate logistic regression analysis showed that age,gender,hyperglycemia,high cholesterol,high blood pressure,waist circumference and creatinine were the independent influencing factors of CAVI（P〈0.05）. Conclusion：The increasing of age,high blood sugar,high blood pressure and abnormal creatinine significantly associate with CAVI. Thus,the screening of atherosclerosis and controlling of the blood glucose,blood pressure and creatinine in the elderly can delay the progression of atherosclerosis.