ZJU指数筛查对健康体检人群非酒精性脂肪肝患病风险预测的价值评估:一项基于重庆市体检人群的单中心研究

Prevalence of nonalcoholic fatty liver disease in health medical examination participants from Chongqing:a single-center study based on the ZJU index

目的:通过ZJU指数筛查我院30 826例体检人群中非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)的患病率及人群分布特点。方法:对体检人群的人体测量学和生化指标进行分析,计算ZJU指数数值。将研究对象按年龄、性别分组,基于ZJU指数筛查各组体检人群中NAFLD的患病率,比较不同年龄段和性别间患病率的差异。结果:130 826例研究对象中,基于ZJU指数计算所得NAFLD的患病率为34.83%,其中男性患病率显著高于女性患病率(40.53%vs.29.26%,χ~2=431.440,P=0.000);2在男性人群中,NAFLD最低患病率为21.67%,分布于<30岁年龄段;最高患病率为49.90%,分布于50~59岁年龄段,总体患病率呈先上升后下降的趋势(P_(trend)=0.000);3在女性体检人群中,NAFLD最低患病率为8.86%,分布于<30岁年龄段,最高患病率为58.70%,分布于≥70岁年龄段,总体患病率随着年龄的增长而呈现上升趋势(P_(trend)=0.000)。结论:我院体检人群NAFLD的总体患病率为34.83%。其中,男性人群为40.53%,女性人群为29.26%,且患病趋势随着年龄的增长而升高。

Objective：To investigate the prevalence and to analyze the population distribution of nonalcoholic fatty liver disease（NAFLD）in 30 826 medical participants in Chongqing based on the ZJU index. Methods：Anthropometric measurements and biochemical parameters were collected,and ZJU index was calculated. Statistical analysis was performed according to age,gender difference and state of NAFLD to identify the prevalence of NAFLD in the cohort. Results：Within 30 826 participants,the prevalence of NAFLD was 34.83%,while the prevalence in male sex was significantly higher than that of female sex（40.53% vs. 29.26%,χ2=431.440,P=0.000）. In male sex,the prevalence of NAFLD ranged from 21.67% to 49.90%. Whilst,it ranged from 8.86% to 58.70% in the female cohort. Overall,the prevalence presented a trend of rise first then fall in male as well as increased with age in female（Ptrend=0.000）. Conclusion：The overall prevalence of NAFLD was 34.83%;the prevalence was 40.53% and 29.26% for male and female,respectively. The prevalence increases with the increasing of age in general cohort in Chongqing.