白细胞介素12家族在银屑病发病机制中的研究进展

Interleukin-12 family cytokines in the pathogenesis of psoriasis

银屑病是一种由T细胞介导的慢性炎症性皮肤病，而白细胞介素12家族细胞因子对T细胞的分化及作用至关重要。白细胞介素12家族包括白细胞介素12、23以及近年来新发现的白细胞介素27和白细胞介素35。从白细胞介素12家族及其成员在银屑病发病机制中的研究发现，白细胞介素12家族具有促炎症和抑制炎症的双重作用，可以调节多种效应细胞的功能，也参与一些信号通路的调节，因此，在银屑病发病机制中发挥着重要作用。

Psoriasis is a chronic inflammatory skin disease mediated by T cells, and interleukin-12 （IL-12） family cytokines play a critical role in the differentiation and function of T cells. The IL-12 family includes IL-12, IL-23 and the newly discovered cytokines IL-27 and IL-35. Several researches have revealed that the IL-12 family not only promotes but also inhibits inflammatory responses, regulates functions of multiple effector cells, and participates in the modulation of some signaling pathways. Therefore, the IL-12 family plays an important role in the pathogenesis of psoriasis.