致康胶囊联合质子泵抑制剂治疗非静脉曲张性上消化道出血的临床疗效

Clinical efficacy of Zhikang capsules combined with esomeprazole for patients with nonvariceal upper gastrointestinal bleeding

目的探究致康胶囊联合注射用埃索美拉唑钠治疗非静脉曲张性上消化道出血的临床疗效.方法选取2015-03/2016-03淄博市第一医院收治的非静脉曲张性上消化道出血患者120例,按治疗方案不同随机分组,为A组(对照组)和B组(治疗组),每组各60例.对照组注射用埃索美拉唑钠(40 mg,2次/d).B组在A组治疗上加用口服致康胶囊(3粒/次,3次/d).两组患者均治疗7 d.观察两组的临床疗效,同时比较两组临床有效率、72 h止血成功率、腹痛缓解时间及不良反应发生率.结果B组的临床总有效率和72 h止血率均比A组高(95.00%vs 83.33%,83.33%vs 71.67%),差异有统计学意义(P<0.05).B组腹痛缓解时间与A组相比较缩短了,差异有统计学意义(P<0.05).B组的不良发生率比A组低(8.33%vs 13.33%),差异无统计学意义(P>0.05).结论致康胶囊联合注射用埃索美拉唑钠治疗非静脉曲张性上消化道出血出血其临床疗效明显,提高止血效果,减轻临床症状,不良反应较少并缩短住院时间,具有一定的应用价值,值得临床推广.

AIM To evaluate the clinical efficacy of Zhikang capsules combined with esomeprazole in the treatment of patients with nonvariceal upper gastrointestinal bleeding.METHODS One hundred and twenty patients with nonvariceal upper gastrointestinal bleeding treated at the First Hospital of Zibo from March 2015 to March 2016 were selected and randomly divided into either a control group（A） or a treatment group（B）,with 60 cases in each group.Group A was treated with intravenous esomeprazole（40 mg,twice a day）.Group B was treated with esomeprazole plus oral Zhikang capsules（3 capsules once,3 times/ d）.The treatment lasted 7 d in both groups.The clinical efficacy,72-h hemostasis rate,abdominal pain time and incidence of adverse reactions were compared between the two groups.RESULTS The overall clinical effective rate was significantly higher in group B than in group A（95.00%vs 83.33%,P〈0.05）.The 72-h hemostasis rate was also significantly higher in group B than in group A（83.33%vs 71.67%,P〈0.05）.The time of abdominal pain was significantly shorter in group B than in group A（P〈0.05）.The rate of adverse reactions was lower in group B than in group A（8.33%vs13.33%）,but the difference was not statistically significant（P〉0.05）.CONCLUSION Compared with esomeprazole alone,Zhikang capsules combined with esomeprazole has better clinical efficacy,can significantly improve hemostasis and reduce symptoms,and is associated with fewer side effects and shorter hospital stays in the treatment of nonvariceal upper gastrointestinal bleeding.