早产儿血清降钙素原水平及其影响因素分析

Analysis of Serum Procalcitonin Levels and Influencing Factors in Premature Infants

目的探讨早产儿血清降钙素原(PCT)水平及其影响因素。方法选取2013年4月-2014年9月我院妇产科出生的新生儿134例,根据胎龄分为早产儿组70例和足月儿组64例,比较2组血清PCT水平,使用单因素分析及多元Cox逐步回归分析其影响因素。结果早产儿PCT水平高于足月儿(P<0.01)。多元Cox逐步回归分析发现,胎龄、存在感染性疾病、胎膜早破为影响新生儿PCT水平的相关因素(P<0.01)。结论早产儿血清PCT水平高于正常足月儿,且其影响因素为胎膜早破、胎龄及感染性疾病。

Objective To investigate the serum level of procalcitonin （PCT） and its influencing factors in premature in- fants. Methods A total of 134 cases of newborns in our hospital between April 2013 and September 2014 were selected and divid- ed into full-term group （n = 64） and premature group （n = 70 ） according to the gestational age of infants. Serum PCT in the two groups was compared and the factors influencing the serum levels of PCT were analyzed by single factor analysis and multiple stepwise Cox regression. Results The level of PCT in premature group was significantly higher than that in full-term group （ P〈0. 01 ）. The results of multivariate Cox regression analysis showed that gestational age, infectious diseases and premature rupture of membranes were related factors of PCT changes in premature infants （P〈0.01）. Conclusion The level of serum procalcitonin in premature infants is higher than that in fullterm infants. Premature rupture of fetal membranes, gestational age and infectious dis- eases can increase serum procaleitonin levels in premature infants.