超声造影在乳腺癌诊断及新辅助化疗疗效评估中的应用价值

Value of Contrast-Enhanced Ultrasound in Diagnosis of Breast Cancer and Evaluation of Therapeutic Effect of Neoadjuvant Chemotherapy

目的探讨超声造影在乳腺癌诊断及新辅助化疗(NAC)疗效评估中的应用价值。方法选取2013年10月-2014年11月收治的乳腺癌患者56例,分别于NAC前后给予普通乳腺超声与超声造影检査,观察两种检査方式对乳腺癌病灶的检出率、NAC前后病灶大小变化及ROI参数变化水平。结果超声造影对乳腺癌病灶阳性检出率高于普通乳腺超声(P<0.05)。NAC前两种检查方式测量病灶横径、上下径比较差异均无统计学意义(P>0.05);NAC后测量病灶最大横径、上下径均小于化疗前(P<0.05)。NAC前后超声造影检查曲线上升斜率、始增时间、峰值时间比较差异无统计学意义(P>0.05),而化疗后峰值强度、曲线下面积低于NAC前(P<0.05)。结论超声造影检查乳腺癌病灶灵敏度高,可对乳腺癌患者NAC后的疗效进行评估,指导临床制定合理治疗方案。

Objective To investigate the value of contrast-enhanced ultrasound in the diagnosis of breast cancer and eval- uation of the efficacy of neoadjuvant chemotherapy（NAC）. Methods A total of 56 patients with breast cancer hospitalized in our hospital between October 2013 and November 2014 were examined by conventional mammography and contrast-enhanced ultra- sonography before and after NAC. Then, the diagnostic rate, changes of the lesion diameter and ROI before and after NAC were compared. Results The positive detection rate of common breast ultrasound in 56 cases was lower than that of contrast - enhanced ultrasound （P〈0.05）. There was no significant statistical significance in the transverse diameter and the vertical diameter before and after treatment by two examination methods （ P〉0.05 ）. After treatment, the maximum diameter and the diameter of the le- sionbecame smaller （ P〈0.05 ）. There was no significant difference in the level of WIS, RT or TPP between the two groups（ P〉0. 05 ）. The levels of PI and AUC after treatment decreased （P〈0.05）. Conclusion The sensitivity of breast cancer is high by con- trast enhanced ultrasound, （ （ （ which can be used to evaluate the curative effect of breast cancer patients after neoadjuvant chem- otherapy in order to guide clinical treatment）））不知是否是此意？？？.