丙泊酚和七氟烷对小儿麻醉生化指标影响的比较

Effects comparison of the biochemical indices in pediatric anesthesia between propofol and sevoflurane

目的:探讨比较手术前后血糖、转氨酶、肌酐在小儿丙泊酚全凭静脉麻醉和七氟烷吸入麻醉的安全性。方法:本研究是一个随机临床对照试验。选择接受全身麻醉的小儿患者200例,ASA分级I级,年龄:4~7岁,择期手术时间在60min以内。患儿随机分为两组:丙泊酚全凭静脉麻醉为P组(n=100);七氟烷吸入麻醉为S组(n=100)。手术前和手术后即刻分别抽取静脉血,对患儿血糖、转氨酶(ALT,AST)、肌酐进行实验室检测。结果:手术前和手术后两组患儿的血糖、转氨酶、肌酐均无统计学差异(P>0.05)。结论:生化指标分析显示4~7岁小儿在接受全身麻醉时使用丙泊酚全凭静脉麻醉和七氟醚吸入麻醉是安全的。

Objective： To prove the quality of propofol or sevoflurane general anesthesia in children based on preoperative and postoperative levels of blood sugar,transaminases and creatinine. Methods： Our study was a randomized controlled trial. Two hundred ASA physical I pediatric patients aged 4 to 7 years,the time less than 60 min of elective surgery under general anesthesia,were randomized in two groups based on different approaches： total intravenous anesthesia was used for the propofol group（ n = 100）（ TIVA） and the inhalation technique was used for the sevoflurane group（ n = 100）. Blood sugar,transaminases and creatinine were detected and recorded at pre and post operation. Results： There were on significantly different between the two groups in blood sugar,transaminases（ ALT,AST） and creatinine at preoperative and postoperative（ P〉0. 05）. Conclusion： Analysis of the examined laboratory parameters shows that propofol and sevoflurane provide full security of general anesthesia in pediatric patients.