适应性支持通气与间歇性气道正压通气对老年COPD合并呼吸衰竭患者呼吸力学的影响

Comparative Analysis of Effects on Respiratory Mechanics of COPD Patients with Respiratory Failure by Adaptive Support Ventilation and Synchronized Intermittent Mandatory Ventilation

目的对比适应性支持通气(ASV)与间歇性气道正压通气(SIMV)对慢性阻塞性肺疾病(COPD)合并呼吸衰竭老年患者呼吸力学的影响。方法 96例COPD合并呼吸衰竭患者纳入本次研究。应用自身对照研究方法,对比ASV和SIMV模式参数,包括心率(HR),血压,中心静脉压(CVP)和血气指标等。结果 ASV组患者呼吸频率、潮气量及呼吸道压力峰值均小于SIMV组(P<0.01),每分通气量差异无显著性(P>0.05)。ASV组PaO_2及pH值均显著高于SIMV组(P<0.01)。结论 ASV通气模式可显著改善COPD合并呼吸衰竭患者的临床症状。

Objective To compare the effects of adaptive support ventilation（ASV） and synchronized intermittent mandatory ventilation（SIMV） on chronic obstructive pulmonary disease（COPD） patients with respiratory failure. Methods Eighty-six COPD patients with respiratory failure were recruited in this study. Self-control method was used to compare the effect of ASV and SIMV on the parameters of the ventilation machine, heart rate, blood pressure, central venous pressure （ CVP）, and blood gas markers. Results There was significant difference between the patients in ASV group and those in SIMV group in the respiratory rate, tidal volume, and peak airway pressure（ PIP）, but there was no significant difference in minute ventilation（MV）. Compared with SIMV group, PaO2, pH, and SaO2 values in ASV group were remarkably increased. Conclusion When mechanical ventilation is used in COPD patients with respiratory failure,ASV can significantly improve clinical outcomes.