突发性耳聋患者血液流变学水平及血脂变化的临床意义

The Clinical Significance of Changes in Hemorheology and Serum Lipids Levels in Patients with Sudden Deafness

目的探讨突发性耳聋患者的血液流变学水平变化及血脂变化的临床意义。方法对我院收治的125例(130耳)突发性耳聋患者,均给予常规药物治疗,根据疗效分为观察组(治疗有效患者)和对照组(治疗无效患者)。比较治疗前后两组患者的血液流变学指标,包括红细胞聚集指数(red cell assembling index,RCAI)、红细胞变形指数(erythrocyte deformation index,EDI)、血清比黏度(serum viscosity,SV)、全血高切黏度(high shear viscosity,HSV)、全血中切黏度(middle shear viscosity,MSV)、全血低切黏度(low shear viscosity,LSV)及血脂指标,包括总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇及三酰甘油的水平,并分析其与患者听阈的相关性。结果所有患者经10 d治疗后分为观察组(痊愈+显效+有效,80耳)和对照组(50耳)。观察组的RCAI、SV、HSV、MSV及LSV显著低于对照组,EDI则显著高于对照组,且差异具有统计学意义(P<0.05)。观察组的TC、TG及LDL-C较治疗前显著降低,HDL-C较治疗前显著升高,差异具有统计学意义(P<0.05)。治疗前,两组患者听阈比较差异无统计学意义(P>0.05),患者听阈与SV及LSV呈显著正相关,与HDL-C呈显著负相关(P<0.05);治疗10 d后,观察组听阈显著低于对照组(P<0.05),患者听阈与血液流变学指标及血脂水平无明显相关关系(P>0.05)。结论突发性耳聋患者的血液流变学及血脂水平均显示异常,且患者的听阈与SV及LSV呈显著正相关,与HDL-C呈显著负相关。

Objective To investigate the clinical significance of changes in hemorheology and serum lipids levels in patients with sudden deafness. Methods 125 patients （130 ears） with sudden deafness admitted into our hospital were treated with conventional drug, and divided into the control group and observation group according to medicine treatment effects. The hemorheology index of RCAI, EDI, SV, HSV, MSV, and LSV, and serum lipids index of TC, TG, LDL-C and HDL-C were compared before and after treatment, Their correlation with auditory threshold before and after treatment was analyzed. Results After 10 days of treatment, there were 80 ears in the observation group and 50 ears in the control group according to medicine treatment effects. The RCAI, SV, HSV, MSV, and LSV in the observation group were significantly lower than those in control group, while EDI was markedly higher （P〈0.05）. The TC, TG, LDL-C in the observation group were much lower than those of the control group, while HDL-C was higher （P〈13.05）. Additionally, differences in auditory thresholds between the two groups were not significant （P〉0.05） before treatment, and auditory threshold were positively correlated with SV and LSV, while negatively correlated with HDL-C （P〈0.05）. After 10 days of treatment, auditory thresholds in the observation group were conspicuously lower than that of the control group （P〈0.05）, There was no obvious correlation with serum lipids and hemorheology indexes （P〉0.05）. Conclusion The hemorheology and serum lipids levels in patients with sudden deafness showed abnormal conditions and were positively correlated with SV and LSV, and negatively correlated with HDL-C.