炎症性疾病中细胞色素P450表达调控的研究进展

Research progress on the regulation of cytochrome P450 expression in inflammatory diseases

细胞色素P450(cytochrome P450,CYPs)是人体内催化外源化合物氧化反应的主要代谢酶,参与了近90%药物的代谢。在炎症性疾病过程中,CYPs家族某些成员的表达可能会下降从而改变药物的代谢表型,对CYPs的诱导或抑制可能改变药物代谢速度,进而影响体内药物的浓度。而在此过程中影响CYPs的机制可能与Th1细胞分泌的IL-1β、IL-2、IL-6、TNF-α、IFN-γ,Th2细胞分泌的IL-4、IL-5、IL-10、IL-13、TGF-β,核受体和microRNA有关。本文综述炎症性疾病中CYPs的调节作用及相关机制,为炎症性疾病临床用药提供参考。

CYPs are a class of enzymes in human that mainly catalyze the oxidation reaction of xenobiotic compounds, and responsible for the metabolism of almost 90 percent of clinical drugs. During inflammation, the expression of some members of the CYPs family may be down regulated and the phenotype of drug metabolism may be changed. CYPs induction or inhibition may change the speed of drug metabolism, as a result, affect the concentration of drugs in vivo. The mecha- nism of the CYPs regulation is probably related to the cytokines, such as IL - 1 β, IL - 2, IL - 6, TNF - α, IFN - γsecreted by Thl cells and IL -4, IL -5, IL - 10, IL - 13, TGF - β secreted by Th2 cells, as well as nuclear receptors and microRNAs. This article reviews the regulatory role of CYPs in inflammatory diseases and its related mechanisms, which will provide reference for clinical drug use during inflammatory diseases.