基于量子点的多分子成像技术在肿瘤微环境研究中的应用

Application of quantum dots-based multimolecular imaging in tumor microenvironment researches

肿瘤的侵袭转移是癌症患者致死的主要原因。癌细胞自身的变化虽可促进肿瘤侵袭转移,但其所处的微环境扮演了更重要的角色。肿瘤微环境是一个复杂的综合系统,由肿瘤细胞和许多基质细胞组成,包括免疫和炎性细胞、血管内皮细胞、成纤维细胞等,在癌发生发展过程中多种成分相互作用,共同促进肿瘤细胞的侵袭转移。然而,传统方法均难以显现多分子与多细胞间的相互作用特征,不能有效展现癌侵袭过程的综合表现。作为一种重要的成像技术,量子点成像由于其优异的光学性能可实现微环境多种成分的原位、实时、定量、多组分、长时间成像,在肿瘤学研究中具有广泛的应用前景。本文主要总结了肿瘤微环境的研究进展,并对基于量子点的多分子成像技术在肝癌、胃癌、宫颈癌、乳腺癌等肿瘤微环境研究中的应用进行了综述。

Tumor invasion and metastasis is the main cause of death among cancer patients. Although the changes of tumor cells themselves can promote this process, the microenvironments of tumor also play a more important role. A tumor microenvironment is a complex system composed of tumor cells and many stromal cells, including immune and inflammatory cells, vascular endothelial cells, fibroblasts, etc., all of which interact with each other to promote the invasion and metastasis of tumor cells in cancer occurrence and development. However, this multimoleeular and muhicellnlar interaction is difficult to observe with traditional labelling methods, and so is the comprehensive performance of cancer invasion process. Quantum dots-based imaging, an important imaging technique with superior optical properties, can achieve real-time, quantitative, multi-component and long-time imaging of mi ents tn situ, thus having extensive application outlook in oncology. This paper mainly reviews the recent progress in researches of tumor micro- environment, and summarizes the application of quantum dots-based multimolecular imaging technology in the study of the microenvi- ronments of hepatoceIlular carcinoma, gastric cancer, cervical carcinoma and breast cancer.