CIK细胞的特点及在消化系统肿瘤免疫治疗中的研究进展

The characteristics of CIK cells and the research progress in immune therapy of digestive system tumors

肿瘤过继细胞免疫治疗(ACI)是一种新的肿瘤治疗技术,是继传统的手术、化疗、放疗等肿瘤治疗方法的又一治疗模式,被Science评选为2013年十项重大突破之首。细胞因子诱导的杀伤细胞(CIK)因其具有独特性、可行性、有效性及安全性等,已成为肿瘤免疫治疗的首选方案,但CIK细胞的杀伤机制尚不完全清楚,而且CIK细胞治疗技术仍处于临床实验阶段,有待进一步深入研究及突破,本文从CIK细胞的生物学特性、杀伤机制以及CIK细胞对于消化系统肿瘤的基础和临床应用的研究进展的几个方面进行综述。

Tumor adoptive cellular immunotherapy is a new tumor treatment technology, is following the traditional surgery, chemotherapy, radiation therapy, and treatment of tumor treatment methods, such as model, has been named by Science for first ten major breakthrough in 2013. Of cytokine induced killer cells（cytokine induced killer cells, CIK cells） because of its uniqueness, feasibility, effectiveness and safety, etc., has become the preferred scheme of tumor immunotherapy, but CIK cells killing mechanism is not fully clear, and CIK cell treatment technology is still in the clinical trials, remains to be further in-depth study and the breakthrough, this paper from the biological characteristics of CIK cells, killing mechanism and CIK cells on the basis of digestive system tumors and summarized the research progress of clinical application of several aspects.