过程分析技术在晶体多晶型研究中的应用

Application of Process Analytical Tools in Polymorphism of Crystalline Materials

过程分析技术(PAT)因其具有"可以实时测量体系中各种参数变化来实现过程开发、优化、设计、分析和调控"的优点,而被广泛应用于工业生产和过程监测中。针对近年来PAT技术在工业结晶领域的应用,在对几种常用PAT技术的工作原理进行介绍的基础上,重点阐述了过程拉曼光谱(Raman)、衰减全反射傅里叶变换红外光谱(ATR-FTIR)、聚光束反射测量仪(FBRM)和粒子影像测量系统(PVM)在工业结晶过程中多晶型溶解度的测量、多晶型成核以及多晶型转晶方面的应用。上述PAT技术在结晶过程中的应用,有助于进一步了解结晶过程机理,进而有助于指导工业结晶过程的开发、优化、设计和放大。

Process analytic technology/tools （PAT） are widely used in industrial production and process monitoring with the advantages that the system can be developed, designed, analyzed and controlled through timely measurement of varieties of parameters, with the goal of ensuring final product quality. In view of the wide application of PAT in the field of crystallization, firstly, the working principle of several PAT tools were briefly introduced. The application of Raman （ Raman）, attenuated total reflection Fourier transformed infrared spectroscopy（ATR-FTIR） , focused beam reflectance measurement （FBRM） and parti- cle vision measurement （PVM） in the determination of solubility, the detection of nucleation and the trans- formation of polymorphic systems were summarized and discussed in detail. The successful application of PAT will promote the further understanding of the mechanism of crystallization process and will help to guide the development, optimization, design and scaling up of the industrial crystallization process.