摘要
将有机硅RAFT试剂三甲氧基硅基丙基三硫代羰基苄基酯(BTPT)固载于硅球表面,通过可逆加成-断裂链转移自由基聚合表面接枝法制备了pH值、温度双敏感聚合物聚甲基丙烯酸-2-(二甲氨基)乙酯(PDMAEMA)修饰的纳米硅球,通过表面保护法在常温下用氨水对该修饰过的硅球进行刻蚀,制得PDMAEMA修饰的纳米空心介孔硅球(HMS@PDMAEMA)。通过核磁、红外、GPC和透射电子显微镜等方法对其结构和表面形貌进行了表征,并用纳米粒度及zeta电位仪测试了其pH值响应行为,预测HMS@PDMAEMA在癌症药物的控制释放和基因递送等领域具有潜在的应用价值。
Trimethoxysilyl-propyl-trithiocarbonyl-benzyl ester(BTPT) , which is one of the silicone-based RAFT agents, was grafted onto the surface of silica nanospheres. Using the reversible addition-fragmenta- tion chain transfer polymerization, silica nanospheres modified with the pH-and temperature-sensitive polyelectrolyte poly(N, N-dimethylaminoethyl methacrylate) (PDMAEMA) were prepared. Then silica nanospheres grafted with PDMAEMA were transformed to the hollow mesoporous structure by surface-protected etching strategy using ammonia at ambient temperature, thereby obtained the hollow mesoporous silica nanospheres modified with the PDMAEMA (HMS@ PDMAEMA). The resultant composite nanop- articles with pH-and temperature-sensitive polymer shell and HMS core were characterized by a variety of techniques such as 1HNMR, FTIR, GPC and TEM, etc. The pH-sensitive behavior was tested by nano- size and zeta potential analyzer. We envision that the HMS@ PDMAEMA should have potential applica- tions in controlled release of anticancer drug and gene delivery.
作者
钟庆
张建华
郭睿威
Zhong Qing Zhang Jianhua Guo Ruiwei(School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, Chin)
出处
《化学工业与工程》
CAS
CSCD
2017年第2期50-54,共5页
Chemical Industry and Engineering
关键词
纳米空心介孔硅球
表面修饰
聚合物
pH值响应性
hollow mesoporous silica nanoparticles
surface modification
polymer
pH-sensitive behavior