1%卢立康唑乳膏与1%特比萘芬乳膏治疗股癣的随机、对照、双盲研究

A randomized,double-blind,controlled study with luliconazle cream(1%)versus terbinafine cream(1%)in patients with tinea cruris

目的观察和评价1%卢立康唑乳膏治疗股癣的疗效和安全性。方法采用随机、双盲的原则将60例真菌镜检阳性的患者分为两组,治疗组外用1%卢立康唑乳膏,每天1次;对照组外用1%特比萘芬乳膏,每天1次。用药疗程均为2周。在开始用药后第1、2、4、8周评价临床和真菌学疗效。结果 60例患者均进入疗效分析。用药1周时,治疗组及对照组临床有效率分别为40%和23.3%,真菌清除率为23.3%和20%,用药2周时,治疗组及对照组临床有效率分别为80%和70%,真菌清除率为70%和63.3%,停药后6周,治疗组及对照组临床有效率分别为83.3%和70%,真菌清除率为80%和66.7%。结论 1%卢立康唑乳膏外用治疗股癣能迅速改善症状,复发率低,是安全有效的外用药物。

Objective To observe and assessment of the efficacy and safety of luliconazole cream（1%）in patients with tinea cruris.Method Sixty patients positive for fungal elements on direct microscopy were equally and randomly divided into 2groups：experimental group applying luliconazole cream（1%）once daily for 2weeks,control group applying terbinafine cream（1%）once daily for2 weeks.Efficacy was assessed on week 1,2,4,8after initiation of treatment.Result 60 patients were eligible for the efficacy analysis.On week 1after initiation of treatment,the clinical effective rate in the experimental group and control group was 40% VS 23.3%,the fungal clearance rate was 23.3% VS 20%.On week 2after initiation of treatment,the clinical effective rate in the experimental group and control group was 80% VS 70%,the fungal clearance rate was 70% VS 63.3%.On week 6after the end of treatment,the clinical effective rate in the experimental group and control group was 83.3% VS 70%,the fungal clearance rate was 80% VS 66.7%.Conclusion Luliconazole cream（1%）have strong ability in relieving signs and symptoms of patients and low recurrence rate.Luliconazole cream（1%）is effective and well tolerated in the treatment of tinea cruris.