不同剂量阿托伐他汀治疗慢性硬膜下血肿研究

Study on the different doses of atorvastatin in the treatment of chronic subdural hematoma

目的观察不同剂量阿托伐他汀治疗慢性硬膜下血肿的作用。方法选择2015年1月~2016年3月瑞安市人民医院住院或门诊治疗的40例慢性硬膜下血肿患者,均经头颅CT检査确诊,随机将患者分为实验组A15例,实验组B15例,对照组10例,实验组A给予10 mg阿托伐他汀口服3个月,实验组B给予20 mg阿托伐他汀口服3个月,对照组未给予阿托伐他汀。治疗结束后,比较三组患者1个月后、2个月后、3个月后头颅CT变化及临床症状变化。结果 30例实验组中有效25例,无效5例,其中2例因临床症状加重改用手术治疗,1例因药物不良反应停药治疗,实验组各组之间临床疗效无明显差异。10例对照组中无效8例,其中6例手术治疗。结论不同剂量阿托伐他汀保守治疗慢性硬膜下血肿安全有效。

Objective To observe the effect of different closes of atorvastatin in the treatment of chronic subdural hematoma.Methods A total of 40 patients with schronic subdural hematoma who were admitted to Rui＇an People＇s Hospital for inpatient or outpatient treatment from January 2015 to March 2016 were diagnosed by head CT.Patients were randomly divided into experimental group A of 15 cases,experimental group B of 15 cases,and control group of10 cases.The experimental group A was orally given 10 mg atorvastatin for 3 months,the experimental group B was orally given 20 mg atorvastatin for 3 months,and the control group was not given atorvastatin.At the end of treatment,the changes of head CT and clinical symptoms after one month,two months and three months were compared between the three groups.Results Among 30 cases in the experimental group,25 cases were effective and 5 cases were ineffective.2 cases were treated by surgical treatment due to exacerbation of clinical symptoms.One patient was discontinued due to adverse drug reactions.There was no significant difference in clinical efficacy between the experimental groups.Among 10 cases in the control group,8 cases were ineffective,and 6 cases were given surgical treatment.Conclusion Different doses of atorvastatin are safe and effective in the conservative treatment of chronic subdural hematoma.