摘要
心血管疾病是临床常见病,也是危害人类健康的重要疾病。越来越多的研究表明,炎性因子在心血管疾病中发挥了重要作用,粥样斑块形成的开始、过程和最终破裂均有炎性因子的参与。炎性因子可用于心血管疾病的预测、诊断、病情监测及预后。本文就近年来临床试验较多的炎性因子,如C-反应蛋白(CRP)、白细胞介素(IL)、脂蛋白相关磷脂酶A2(Lp-PLA2)、髓过氧化物酶(MPO)、血清淀粉样蛋白A(SAA)、肿瘤坏死因子α(TNF-α)、可溶性CD40配体(sCD40L)等,对其研究进展和临床应用展开讨论。
Cardiovascular disease is a common clinical disease,but also an important disease which seriously endangers human health.More and more studies showed that inflammatory factors which involve in the initiation,progression,and final rupture of atherosclerotic plaques,play a crucial role in cardiovascular disease.Inflammatory cytokines can be used for prediction,diagnosis,condition monitoring and prognosis of angiocardiopathy.In this study we aimed at reviewing inflammatory factors with more clinical trials,such as C-reactive protein（CRP）,interleukin（IL）,lipoproteinassociated phospholipase A2（Lp-PLA2）,myeloperoxidase（MPO）,serum amyloid A（SAA）,tumor necrosis factor-alpha（TNF-α）,soluble CD40 ligand（sCD40L）,and the research progress and clinical application of these markers are discussed.
出处
《中国现代医生》
2017年第1期157-161,共5页
China Modern Doctor
关键词
动脉粥样硬化
C-反应蛋白
脂蛋白相关磷脂酶A2
髓过氧化物酶
肿瘤坏死因子Α
Atherosclerosis
C-reactive protein（CRP）
Lipoprotein-associated phospholipase A2（Lp-PLA2）
Myeloperoxidase（MPO）
Tumor necrosis factoralpha（TNF-α）
