流感病毒膜蛋白M2e应用研究进展

Progress in application of influenza virus membrane protein M_2e

流行性感冒是一种传染性较高的急性呼吸道疾病，极大地威胁了人类健康。由于流感病毒易发生变异，致目前的防治措施不能及时有效地应对，使防治效果严重降低。流感病毒膜蛋白M2e（extra-cellulardomainoftheM2protein）高度保守，是流感病毒的通用性作用靶点，基于M2e的免疫预防措施可提供广谱的保护作用。M2e疫苗及M2e抗体已成功在动物模型中发挥抗流感作用，临床应用则报道较少，因而研究M2e对于流感病毒的防治具有重要意义。

Influenza is a highly contagious acute respiratory disease, and a public health problem. As the influenza virus is easy to change, the current prevention and control measures are not and effective. The extracel- lular domain of the M2 protein （M2e） of influenza virus is highly conserved, which is a universal target of anti-in- fluenza virus treatment. Immune preventive measures based on M2e can provide a broad spectrum of protective effects. M2e vaccine and M2e monoclonal antibody successfully inhibited the infection and spread of influenza vi- rus in animal models. This review focus on the progress of researches on the application of M2e protein.