摘要
磷酸酶及张力蛋白同源物诱导的蛋白激酶(PINK1)/Parkin介导的线粒体自噬在多种疾病的发生发展中起到了重要作用。对PINK1/Parkin介导的线粒体自噬进行研究,包括PINK1和Parkin的生物学特性及PINK1/Parkin介导的线粒体自噬的生物学作用,希望将来人类通过对线粒体自噬的调控来治疗临床疾病有所提示。
The mitochondrial autophagy mediated by phosphatase and tensin homolog induced putative ki- nase 1 ( PINK1 )/Parkin plays an important role in the development of a variety of diseases. The latest research pro- gress of the mitochondrial autophagy mediated by PINK1/Parkin was discussed in this review,including the biological characteristics of PINK1 ,Parkin and the biological roles of mitochondrial autophagy mediated by PINK1/Parkin.
作者
金呈强
李金珂
贾彦霞
Jin CQ Li JK Jia YX(Clinical Laboratory ,Affiliated Hospital of Jining Medical University, Jining 272029, China Pudong New Area Community Health Service Center, Shanghai 201311, China Department of Radiology, the First People's ttospital of Jining , Jining 272000, China)
出处
《国际免疫学杂志》
CAS
2017年第1期92-95,共4页
International Journal of Immunology
基金
基金项目:山东省高等学校科技计划项目(J15LL11)
山东省医药卫生科技发展计划项目(2013WS0337)
山东省中医药科技发展计划项目(2015-244)
济宁市科技发展计划项目(2014jnnk23)