竞争性内源RNA与消化系恶性肿瘤关联的研究进展

Progress in research of competing endogenous RNAs related to gastrointestinal cancers

竞争性内源RNA(competing endogenous RNA,ce RNA)是一种相互作用的R N A转录本,通过竞争性结合并降低靶标微小RNA(micro RNA,miRNA)的水平,解除信使RNA(messenger RNA,m RNA)的抑制作用.miRNA、mRNA、长链非编码RNA、假基因、环形RNA之间形成了密不可分的网络,通过这种复杂的网络互相调节各自的表达水平,从而参与一系列的生物学行为,包括肿瘤的发生.肿瘤相关性ce RNA在消化系肿瘤的形成过程中发挥关键作用,我们对消化系肿瘤相关性ce RNA做简要综述,并简单分析其与靶标mi RNA的相互作用,为进一步理解ce RNA介导的肿瘤生成分子机制提供新思路.

Competing endogenous RNAs（ceRNAs） are RNA transcripts which can communicate with each other by sponging and decreasing target microRNAs（miRNAs） and thus de-repressing messenger RNAs（mRNAs）.ceRNAs have crucial roles in oncogenic pathways involved in many types of gastrointestinal cancers by sponging miRNAs.Here,we review oncocerrelated findings found up to now and analyze the cross-talk between ceRNAs and miRNAs,with an aim to give a novel perspective to the understanding of oncocer-mediated mechanisms in gastrointestinal cancers.