青枯雷尔氏菌噬菌体研究进展

Research Progress of Bacteriophages Infecting Ralstonia Solanacearum

烟草等茄科植物青枯病的防治是世界性难题,传统的化学方法、轮作及种植抗病品种等都不能有效控制该病害。探索一种新型、有效的生物防治方法——"噬菌体疗法"成为近年来研究的热点。噬菌体应用于细菌性疾病或病害的防治可以追溯到上世纪初,然而伴随着抗生素的发现和广泛应用,噬菌体疗法在相当长的时间里被忽略。近年来,随着耐药性细菌和超级细菌的出现,利用噬菌体防控细菌性疾病和病害的研究越来越受到人们的重视。本文简单阐述了噬菌体的早期研究与复苏的历史,青枯雷尔氏菌噬菌体的获得方法、分类及潜在应用,指出了噬菌体应用研究中存在的问题,并对其以后的发展进行了展望。

Bacterial wilt is a destructive disease caused by Ralstonia solanacearum and it is distributed in many countries of the world. This disease commonly occurrs in many plants, such as tobacco, eggplant and tomato, etc. Traditional methods, such as using chemicals, crop rotation, planting disease - resistant variety and regulating seedling transportation are not fully effective in controlling this plant disease. Therefore, to exploit an alternative newly and highly effective control method, the phage therapy was highlighted in recent years. Historically, the study of using bacteriophages to control bacterial diseases in human and plants can be dated back to the beginning of the last century; however, with the development and wide application of antibiotics, the phage therapy was neglected for a long times. Recently, with the appearance of drug - resistant bacteria and superbacteria, the study of using phage therapy to control bacterial diseases has been paid much attention. In this paper, we briefly reviewed the initial and revival research history of phages, the method of isolation, taxonomy and potential application of phages infecting Ralstonia solanacearum. Finally, several problems and future research tendencies of phage therapy were also pointed out.