长链非编码RNA与结直肠癌诊断、治疗及预后的研究进展

Research progress in long non-coding RNA and the diagnosis, treatment and prognosis of colorectal cancer

长链非编码RNA(long non-coding RNA,Lnc RNA)是一类长度>200个核苷酸,且不具备蛋白质编码功能的RNA分子。异常表达的Lnc RNA通过多种分子机制参与肿瘤的发生和发展。结直肠癌是常见的恶性肿瘤之一,其筛查、诊断及个性化治疗方案仍有待改善。异常表达的Lnc RNA与结直肠癌患者不同肿瘤分期等临床病理特征间的联系体现了Lnc RNA成为结直肠癌诊断、治疗及预后靶标的潜能。本文对Lnc RNA在结直肠癌中的表达及其作用进行综述。

Long non-coding RNAs （LncRNAs） is a group of non-coding RNAs with length exceeding 200 bp that can not code complete protein. Dysregulation of LncRNAs is involved in various molecular mechanisms and has a significant role in occurrence and development of tumor. Colorectal cancer （CRC） is one of the most common cancer. The screening, diagnosis and personalized treatment of CRC are urgent to be improved. Dysregulation of LncRNAs is related to tumor stage and clinicopathological features of CRC, which have been suggested to be used as novel potential biomarkers for diagnosis, prognostic prediction and treatment of CRC. This review summarizes the advances in expression and role of LncRNAs in CRC.