超敏C反应蛋白和脑钠肽及脂联素水平与冠心病患者相关性

Correlation between patients with coronary heart disease and the level of high-sensitivity C-reactive protein and brain natriuretic peptide and adiponectin level

目的探讨超敏C反应蛋白(hs-CRP)、脑钠肽(BNP)、脂联素(APN)水平的变化对冠心病发生、发展及预后的影响。方法将528例受试者分为对照组(同时期健康的体检者)250例和试验组(冠心病患者)278例,并将试验组根据冠心病的临床类型分为急性心肌梗死(AMI)组40例、不稳定型心绞痛(UPA)121例、稳定型心绞痛患者(SAP)组117例。用胶乳免疫比浊法检测2组患者血清中的hs-CRP含量;用化学免疫发光微粒子检测试验组患者血清中的BNP的含量;用酶联免疫法分别测定试验组患者血清中的APN的含量。结果对照组和试验组血清hs-CRP分别为(3.78±2.12),(7.29±5.98)mg·L^(-1),差异有统计学意义(P<0.05),血清APN含量分比为(81.21±20.89),(1423.89±1389.21)pg·m L^(-1),差异有统计学意义(P<0.05);血清BNP水平分别为(929.23±312.67),(412.34±299.89)μg·m L^(-1),差异有统计学意义(P<0.05)。在冠心病试验组中,hs-CRP浓度与BNP水平无相关性,差异无统计学意义(P>0.05);hs-CRP与APN呈负相关(r=-0.567),差异有统计学意义(P<0.05);BNP和APN无相关性,差异无统计学意义(P>0.05)。结论冠心病患者血清hs-CRP、血清APN和血清BNP水平的变化程度与冠心病的发展程度有着密切的联系,是冠心病发生的危险因素。

Objective To study the effect of high-sensitivity C-reactive protein（ hs-CRP）,brain natriuretic peptide（ BNP）,adiponectin（ APN） on coronary heart disease（ CHD） occurrence,clinical course and prognosis,as well as the correlation among different types of coronary heart disease. Methods A total of 528 cases were divided into control group（ same period of healthy volunteers） with 250 cases and the treatment group（ CHD patients） with 278 cases,and the treatment group was divided into three groups according to clinical types of coronary heart disease： acute myocardial infarction（ AMI） group with 40 cases,unstable angina pectoris（ UPA） group with 121 cases,stable angina pectoris（ SAP） group with 117 cases. In treatment group,the serum hs-CRP concentration were detected by latex immune ratio; and the serum BNP concentration was determined by chemiluminescence microparticle immuno assay; the serum APN concentration was measured by ELISA.Results In control group and treatment group,the serum hs-CRP were（ 3. 78 ± 2. 12）,（ 7. 29 ± 5. 98） mg·L-1,the difference was statistically significant（ P〈0. 05）; the serum APN content division ratio of（ 81. 21 ± 20. 89）,（ 1423. 89 ± 1389. 21） pg·m L-1,the difference was statistically significant（ P〈0. 05）; the serum BNP levels were（ 929. 23 ± 312. 67）,（ 412. 34 ± 299. 89） μg·m L-1,the difference was statistically significant（ P〈0. 05）. In the treatment group of coronary heart disease,hs-CRP concentration and BNP were not correlated,the difference was not statistically significant（ P〈0. 05）. There was a negative correlation（ r =-0. 567） and a statistically significant（ P〈0. 05） between hs-CRP and APN. No correlation and no significant difference were found between BNP and APN（ P〈0. 05）. Conclusion The serum hs-CRP,APN and BNP levels were closely related to the development of coronary heart disease,thus they are considered as risk factors for coronary heart disease.