血清25-(OH)维生素D3与糖尿病周围神经病变严重程度的相关性

Relationship of serum 25-hydroxy vitamin D3 with the severity of diabetic peripheral neuropathy

目的:分析2型糖尿病合并糖尿病周围神经病变(DPN)患者血清25-(OH)维生素D3(25-(OH)D3)水平变化,探讨其与神经病变严重程度的关系,为DPN的防治提供理论依据。方法:单纯糖尿病患者50例,糖尿病周围神经病变患者150例,用化学发光法测定患者血清25-(OH)D3水平,用TCSS评分对其进行病变程度分层分析。结果:糖尿病周围神经病变患者血清25-(OH)D3为(27.18±7.89)nmol/L,低于单纯糖尿病患者的(42.87±12.54)nmol/L,P<0.05;血清25-(OH)D3水平与TCSS评分分层分析呈等级依赖性。结论:随着糖尿病周围神经病变严重程度增加,血清25-(OH)D3水平降低。

Objective：To study the relationship between serum level of 25-hydroxy vitamin D3 and the severity of neuropathy in patients with type 2diabetes mellitus（T2DM）combined with diabetic peripheral neuropathy（DPN）.Provide theoretical basis for the prevention and treatment of DPN.Methods：The level of serum 25-hydroxy vitamin D3 were detected by the method of radioimmunoassay.TCSS score system for grading of nerve lesion.There were 50 cases diabetes without peripheral neuropathy,150 cases of diabetic peripheral neuropathy,to observe the correlation of serum 25-hydroxy vitamin D3 level and TCSS score in patients with diabetic peripheral neuropathy.Results：The level of serum 25-hydroxy vitamin D3 in diabetic peripheral neuropathy patients（27.18±7.89）nmol/L was lower than that in diabetes without peripheral neuropathy（42.87±12.54）nmol/L,P〈0.05.Serum 25-hydroxy vitamin D3 level and TCSS score were rank dependent.Conclusion：Serum 25-hydroxy vitamin D3 level was closely related to the severity of diabetic peripheral neuropathy.