摘要
目的:研究固本舒喘颗粒的平喘、止咳、祛痰作用。方法:采用大鼠卵白蛋白致敏法、小鼠浓氨水引咳法和酚红祛痰法观察不同剂量固本舒喘颗粒对大鼠引喘潜伏期、小鼠咳嗽次数和酚红排泌量的影响。结果:与模型组比较,各剂量固本舒喘颗粒均能显著延长大鼠引喘潜伏期,增加小鼠酚红排泌量(P<0.05或P<0.01);中、高剂量固本舒喘颗粒能明显降低小鼠咳嗽次数(P<0.01)。结论:固本舒喘颗粒具有一定止咳、平喘、祛痰的功效。
Objective: To study the antiasthmatic, antitussive, and expectorant effects of Guben Shuchuan Granule (GSG). Method: Observed the effect of different doses of Guben Shuehuan Granule on asthma incubation period of rats, cough times and phenolsulfonphthalein excretion volume of mice by sensitization method induced by rat ovalbumin, coughing induced by strong ammonia and phenol red expectoration method in mice. Result: Compared with the model group, each dose of GSG significantly prolonged the incubation period of asthma and increased the phenol red? excretion quantity (P 〈 0.05 or P 〈 0.01 ). Medium and high dose of GSG obviously reduced the cough times of mice (P 〈 0.01 ). Conclusion: GSG has significant effect on antitussive, antiasthmatic and expectorant functions.
作者
俞琦
欧江琴
冯果
田维毅
YU Qi ou Jiang- qin FENG Guo TIAN Wei -yi(Basic Medical College, Guiyang University of Chinese Medicine, Guiyang 550025, Guizhou China The First Affiliated Hospital of Guiyang University of Chinese Medicine, Guiyang 550002, Guizhou China Pharmaceutical College, Guiyang University of Chinese Medicine, Guiyang 550025, Guizhou China)
出处
《贵阳中医学院学报》
2017年第2期16-18,36,共4页
Journal of Guiyang University of Chinese Medicine
基金
贵阳市科技局项目
项目编号:[2008]筑科农合同字第26号
贵州省中药现代化专项项目
项目编号:黔科合中药字[2011]5016号
关键词
固本舒喘颗粒
药效学
止咳
平喘
祛痰
Guben Shuchuan Granule
pharmacodynamics
Antitussive
Antiasthmatic
Expectorant