小胶质细胞内的钙离子信号的研究进展

Calcium Signaling in Microglia

细胞内钙离子(Ca^(2+))对多种生理活动均具有一定的调节作用,它可影响神经递质释放和细胞兴奋性.细胞内钙离子浓度([Ca^(2+)]i)受到多方面调控,[Ca^(2+)]i的变化是重要的信号转导方式之一.小胶质细胞是中枢神经系统中固有的免疫细胞,它们对脑损伤、脑炎症和多种神经退行性疾病有先天性的免疫应答.除了在疾病发生发展中的作用,小胶质细胞也在很大程度上参与了神经元网络的发育和脑组织稳态的维持.受体介导的钙离子信号的传递,是包括小胶质细胞在内的所有细胞中最普遍的信号转导机制.小胶质细胞功能变化与小胶质细胞内钙离子信号的变化密切相关,对小胶质细胞内钙离子信号的研究具有重大的意义.

： Intracellular calcium （Ca2＋） has the regulation to a variety of physiological activities. It can affect the release of neurotransmitter and the excitability of cell. Intracellular calcium concentration（ [ Ca2＋ ]i） subject to many regulatory,the change of [ Ca2 ＋]i is one of the most important pathways of signal transduction. Microglia are inherent immune cells in the central nervous system. They have innate immune response to brain injury, brain inflammation and a variety of neurodegenerative diseases. In addition to roles in disease development, microglia are also heavily involved in the development of neural networks and the homeostasis of neural network. Receptor-mediated calcium signaling transfer is the most common signal transduction mechanisms in all cells, including microglia. The functional changes of microglia are closely related to the changes of calcium signaling in microglia, and it is of great significance for the study of microglia calcium signal.