多巴胺修饰聚乙二醇的合成及与Fe^(3+)配位研究

SYNTHESIS OF DOPAMINE-MODIFIED POLYETHYLENE GLYCOL COMPLEXED WITH Fe^(3+)

利用对硝基苯基氯甲酸酯活化方法合成多巴胺(DOPA)末端修饰的线型聚乙二醇PEG-(DOPA)_2,通过核磁共振技术、紫外-可见分光光度法和动态流变学技术对产物结构和性质进行表征。实验结果表明,多巴胺与PEG-10000的偶联率高达98.0%;随着pH值增大(3.5~12),多巴胺基团与金属Fe^(3+)发生从一配位到稳定三配位结构的转变;在一定聚合物浓度下(≥9%(w/v,重量/体积比),多巴胺基团与Fe^(3+)的物质的量比为3:1)和pH=12时,PEG-(DOPA)_2与Fe^(3+)发生配位,引起PEG聚合物之间的交联,形成PEG-DOPA-Fe^(3+)水凝胶。该凝胶具有pH敏感性和自愈性等多功能性,在生物医学工程和水下机械涂层材料等领域具有潜在应用。

Using p-nitrophenyl chloroformate as the activating agent,the synthesis of a dopamine modified linear PEG polymer PEG-（DOPA）2 was studied,the compound is characterized by UV-Vis and NMR spectroscopy as well as Rheology.Experimental results show that PEG-10000 is modified with dopamine groups with high coupling efficiency of 98.0%;with increase of pH from 3.5 to 12,dopamine groups coordinates with Fe^3＋ with stoichiometry changing from monoto tris;at a certain polymer concentration（≥9 %（w/v）,dopa mine：Fe^3＋=3：1） and pH=12,a solution of PEG-（DOPA）2 could coordinate with Fe^3＋ and form a PEG-DOPA-Fe^3＋ hydrogel with multifunctional properties,such as pH sensitive and self-healing ability,having potential uses in biomedical applications as well as underwater adhesives.