摘要
目的采用高效液相色谱-蒸发光散射检测器(HPLC-ELSD)法测定脂肪乳注射液中大豆油在不同条件下的含量变化。方法以硅胶柱,正己烷-异丙醇-冰醋酸(89.9:1.0:0.1)为流动相,ELSD检测。结果温度对本品质量影响较大,宜在25℃条件下贮存。结论脂肪乳注射液在加速试验和长期试验中大豆油的含量符合相关药品标准。
Objective：An HPLC-ELSD method was applied to determine the content change of soybean oil in fat emulsion injections.Methods：A silica gel column was used,with the mobile phase of hexane ：isopropyl alcohol ：glacial acetic acid as 89.9 ：1.0 ：0.1 with the application of ELSD.Results：The results showed that the fat emulsion injections were unstable at high temperature and it should be stored at about 25 ℃.Conclusion：The contents of soybean oil in fat emulsion injections could meet the related drug standard both in the accelerated test and long-term test.
出处
《井冈山大学学报（自然科学版）》
2017年第1期93-96,共4页
Journal of Jinggangshan University (Natural Science)
基金
福建省科技平台建设(福建省生物医药产业中试与检测技术公共服务平台2014Y2008)
福建生物工程职业技术学院科研计划项目(2014kj02)
