异丙酚复合芬太尼在妇科无痛刮宫术中所需剂量与年龄关系的回顾性分析

A retrospective analysis of the relationship between age and dosage of propofol and fentanyl in gynecological painless curettage required in

目的探讨异丙酚复合芬太尼在妇科无痛刮宫术中所需剂量与年龄关系的相关性,以提高手术的有效性和安全性。方法选择行无痛刮宫术的妇女300例,按年龄阶段分为3组,每组均先静脉给以芬太尼1.0μg/kg,3min后以1.5mg/kg的丙泊酚作为诱导剂量静注,术中根据患者对手术刺激的反应追加丙泊酚用量,分别记录术前、扩宫时、吸宫时、清醒后的MAP、HR、RR和SpO_2及麻醉效果,异丙酚总量、手术时间、苏醒时间以及术后并发症(恶心、呕吐、宫缩痛),并观察麻醉满意率。结果三组患者手术时间、苏醒时间及术后并发症比较差异无统计学意义(P>0.05),异丙酚用量1组大于2组,2组大于3组,比较差异有统计学意义(P<0.05)。2组、3组MAP、RR、SpO_2下降明显,比较差异有统计学意义(P<0.05)。结论异丙酚复合芬太尼在妇科无痛刮宫术中安全有效,所需剂量与年龄关系呈负相关性,特别对于年龄大于55岁的异丙酚用量明显减少,且对其MAP、RR、SpO_2影响较大。

Objective To investigate the correlation between age and dosage of propofol and fentanyl in gynecological painless curettage required in,in order to improve the effectiveness and safety of operation. Methods choose painless curettage in 300 cases of women,according to the age stage were divided into 3 groups,each group were first given intravenous fentanyl 1 g/kg,3min to 1. 5mg/kg after the intravenous injection of propofol as induction dose of propofol in patients,according to the amount of operation in response to stimuli,respectively recorded before operation,expanding palace when,when,suction palace awake after the MAP,HR,RR and Sp O2 and the effects of anesthesia,propofol,total operation time,recovery time and postoperative complications（ nausea,vomiting,Gong Suotong）,and to observe the anesthesia satisfaction rate. Results no statistical significance in three groups of patients with operation time,recovery time and postoperative complications of difference（ P〉0. 05）,the dosage of propofol 1 groups of more than 2 groups,2 groups of more than 3 groups,the difference was statistically significant（ P〈0. 05）. The 2 group,3 group of MAP,RR,SpO2 decreased significantly,the difference was statistically significant（ P〈0. 05）. conclusion of propofol and fentanyl in gynecological painless curettage is safe and effective,the required dose was negatively correlated with age,especially for less than 55 years of age significantly reduced the amount of propofol,and the MAP,RR,SpO2 influence.