辽宁住院高血压患者药物利用分析

Antihypertensive drug use among hypertensive inpatients in Liaoning province

目的了解三级甲等医院住院高血压患者降压药的药物利用情况,促进抗高血压药物的合理使用。方法自辽宁省两城市方便抽样选择4家三级甲等医院,随机选取2011年1月1日—2016年1月1日高血压住院患者8 000例,提取病历中抗高血压药物信息,分析抗高血压药物利用情况。结果抗高血压药物使用例次最多的为氨氯地平8.49%(2 055/24 192),用药频度最高的抗高血压药物是缬沙坦(31 391.85),DUI值最大的抗高血压药物是缬沙坦氨氯地平(1.63),DUI值最小的抗高血压药物是咪达普利(0.75),DUI值接近1.0的抗高血压药物分别是氯沙坦(0.98)、尼卡地平(0.99)、美托洛尔(1.01)、厄贝沙坦(1.02)、厄贝沙坦氢氯噻嗪(1.03)。结论辽宁两城市高血压住院患者抗高血压药物利用较合理。

Objective To examine antihypertensive drug use among hypertension patients hospitalized in hospitals of grade III class A in Liaoning province for the promotion of reasonable application of antihypertensive drugs.Methods Using convenient sampling we selected 4 hospitals of grade III class A in 2 cities of Liaoning province.Information on antihypertensive drug use were extracted from medical records of a total of 8 000 hypertension patients hospitalized in one of the 4 hospitals （2 000 patients for each hospital） between January 1,2011 and January 1,2016 and then analyzed statistically.Results The most frequently used antihypertensive drug was amlodipine （8.49%,2 055/24 192 case-times）.For all the antihypertensive drugs utilized,the maximum defined daily doses （DDDs） was 31 391.85 for valsartan; the maximum drug utilization index was 1.63 for valsartan amlodipine; and the minimum drug utilization index was 0.75 for imidapril.The utilized antihypertensive drugs with the drug utilization index approximately to one were losartan （0.98）,nicardipine （0.99）,metoprolol （1.01）,irbesartan （1.02）,and irbesartan hydrochlorothiazide （1.03）,respectively.Conclusion The utilization of antihypertensive drugs is rational for hypertension patients hospitalized in large hospitals in two cities of Liaoning province.