幽门螺杆菌感染对膜性肾病患者的血肌酐和血白蛋白及24小时尿蛋白水平的影响研究

Influence of Helicobacterpyloriinfection on levels of serum creatinine,serum albumin,and 24-hour urine protein of patients with membranous nephropathy

目的探讨幽门螺杆菌感染对膜性肾病患者相关临床指标的实际影响,进而为膜性肾病的相关临床研究提供新思路和指导方向。方法选取医院2014年12月-2015年7月临床收治122例膜性肾病患者为研究对象,根据患者是否感染幽门螺杆菌分为感染组和非感染组,每组61例;针对两组患者血肌酐、血白蛋白和24小时尿蛋白水平以及相关临床炎症因子水平进行观察和比较。结果感染组患者的血肌酐水平为(85.33±11.23)μmol/L,显著高于非感染组(77.38±10.23)μmol/L,且组间比较差异有统计学意义(P<0.05);感染组患者血白蛋白和24小时尿蛋白水平分别为(29.34±9.32)g/L和(6.38±1.02)g/24h,与非感染组患者(29.18±9.77)g/L和(6.41±0.98)g/24h之间的差异不大,且无统计学意义;两组患者的CRP、TNF-α和PCT水平差异不大,无统计学意义。结论幽门螺杆菌感染可导致膜性肾病患者血肌酐升高,在一定程度上加重了患者病情,临床针对幽门螺杆菌感染的膜性肾病患者应给予针对性的干预措施。

OBJECTIVE To explore the actual influence of Helicobacter pylori infection on related clinical indicators of patients with membranous nephropathy so as to provide new ideas and guidance for relevant researches of membranous nephropathy. METHODS A total of 122 patients with membranous nephropathy who were treated in hospitals from Dec 2014 to Jul 2015 were recruited as the study objects and divided into the infection group and the non-infection group according to the status of H. pylori infection, with 61 cases in each group, The levels of serum creatinine, albumin, and 24-hour urine protein as well as related clinical inflammatory factors were observed and compared between the two groups of patients. RESULTS The serum creatinine level of the infection group was （ 85.33 ±11.23）μmol/L, significantly higher than （77.38±10.23）μmol/L of the non-infection group （P〈 0.05）. The serum albumin level of the infection group was （29.34 ±9.32） g/ L, the non-infeetion group （29.18± 9.77） g/ L the 24-hour urine protein level of the infection group was （6.38±1.02）g/24h, the non-infection group （6. 41±0.98）g/24h, and there was no significant difference between the two groups. There was no significant difference in the level of CRP, TNF-α, or PCT between the two groups of patients. CONCLUSION The H. pylori infection may lead to the elevated level of serum creatinine of the patients with membranous nepbropathy and exacerbate the illness condition to certain degree. It is necessary to take targeted intervention measures for the membranous ne- phropathy patients complicated with H. pylori infection.