高剂量氨基酸和脂肪乳肠外营养对合并感染的早产患儿营养状况的影响研究

Influence of parenteral nutrition of high-dose amino acids and fat emulsion on nutritional status of premature infants complicated with infections

目的探究不同肠外营养方式对其营养状况的临床实际影响,为早产合并感染患儿的临床研究实践提供借鉴和参考。方法选取2013年12月-2015年12月收治的早产合并感染患儿88例,根据肠外营养的方式不同将患儿分成高剂量组和低剂量组,各44例;以两组患儿的住院时间、恢复出生体质量时间、恢复出生体质量后体质量增长、肠外营养时间、出院体质量以及并发症发生情况等为观察指标。结果高剂量组患儿住院时间、恢复出生体质量时间和肠外营养时间分别为(12.43±2.51)d、(6.41±1.41)d和(7.41±1.11)d,明显少于低剂量组(14.98±3.49)d、(10.18±3.02)d和(10.29±3.20)d;高剂量组恢复出生体质量后体质量增长情况和出院体质量分别为(28.71±2.51)g/kg/d和(2066.43±244.32)g,明显高于低剂量组(17.02±4.32)g/kg/d和(1901.23±300.21)g;高剂量组和低剂量组患儿并发症发生率分别为0.00%和11.36%,差异有统计学意义(P<0.05)。结论在给予患儿抗菌药物治疗的基础上,采用高剂量氨基酸和脂肪乳的肠外营养方式可以显著改善早产合并感染患儿的营养状况,提升临床的综合治疗效果。

OBJECTIVE To explore the actual clinical effect of different parenteral nutrition approaches on nutritional status of premature infants complicated with infections so as to provide guidance for clinical practice. METHODS A total of 88 premature infants complicated with infections who were treated in the hospital from Dec 2013 to Dec 2015 were enrolled in the study and divided into the high-dose group and the low-dose group according to the par- enteral nutrition status, with 44 cases in each group. The observation indexes, including the length of hospital stay, time of recovery of birth weight, increase of weight after recovery of birth weight, parenteral nutrition time, birth weight at discharge, and incidence of complications, were compared between the two groups of infants. RESULTS The length of hospital stay of the high-dose group was （12.43±2.51）days, significantly shorter than （14. 98±3.49）days of the low-dose group; the time of recovery of birth weight of the high-dose group was （6.41±1.41） days, significantly shorter than （10.18 ±3.02）days of the low-dose group; the parenteral nutrition time of the high-dose group was （7.41± 1.11）days, significantly shorter than （10.29 ± 3.20）days of the low--dose group. The increase of weight after recovery of birth weight was （28. 71±2.51）g/kg/d in the high--dose group, significantly higher than （17.02±4.32）g/kg/d in the low-dose group; the body weight at discharge was （2066.43 ±244.32）g in the high--dose group, significantly higher than （1901. 23±300.21）g in the low-dose group. The incidence rate of complications was 0.00% in the high-dose group, 11.36% in the low-dose group, and there was significant difference （P〈0. 05）. CONCLUSION On the basis of antibiotic therapy, the parenteral nutrition of high-dose amino acids and fat emulsion can significantly improve the nutritional status of the premature infants complicated with infection and raise the comprehensive therapeutic effect.