摘要
构建结直肠癌的动物模型在研究人类结直肠癌的预防与治疗中具有重大意义,而研究肿瘤的发生、发展及转移中扮演重要角色的癌组织局部免疫状态的动物模型尚处于探索阶段。其中局部免疫基因工程模型的研究发展迅速,并在突变结肠干细胞成瘤以及解决因原发肿瘤生长而导致的肠梗阻上取得了突破性进展。由此,一种未来理想局部免疫基因工程模型已展露雏形。
The establishment of animal models of colorectal cancer in the study of human colorectal cancer prevention and treatment has great significance, and the study of tumor occurrence, development and metastasis which plays an important role in the local immune status of cancer animal model is still in the exploratory stage. The study of local immune genetic engineering model has developed rapidly and has made breakthrough progress in mutating colonic stem cell and solving intestinal obstruction caused by primary tumor growth. Thus, an ideal local immune genetic engineering model has been exposed prototype.
作者
秦凯迪
童仕伦
郑勇斌
孙伟
肖旷
宋丹
QIN Kaidi TONG Shilun ZHENG Yongbin SUN Wei XIAO Kuang SONG Dan(Department of Gastrointestinal Surgery, People's Hospital of Wuhan University, Hubei Province, Wuhan 430060, Chin)
出处
《中国医药导报》
CAS
2017年第5期28-30,共3页
China Medical Herald
基金
国家自然科学基金资助项目(81372553)
关键词
结直肠癌
局部免疫状态
基因工程小鼠模型
结肠干细胞
Colorectal cancer
Local immune status
Genetic engineering mouse model
Colon stem ceils