急性脑梗死患者脑动脉狭窄与炎性因子的相关性分析

Correlation between cerebral artery stenosis and inflammatory factors in patients with acute cerebral infarction

目的探讨急性脑梗死患者脑动脉狭窄与炎性因子的相关性。方法 98例急性脑梗死脑动脉狭窄患者,按照脑动脉狭窄程度(TIMI分级)分为I级组29例,II级组41例和III级组28例,选取同期42例健康体检者作为对照组。比较各组颈动脉内膜中层厚度(IMT)、颈总动脉的扩张性、僵硬度、斑块指数和肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)水平,分析脑动脉狭窄程度与炎性因子的相关性。结果 I、II、III级组患者的IMT、僵硬度、斑块指数及TNF-α、IL-6、CRP水平均显著高于对照组,扩张性显著低于对照组;三组间上述指标比较差异也有统计学意义。IMT、僵硬度、斑块指数与TNF-α、IL-6及CRP水平呈正相关,扩张性与TNF-α、IL-6及CRP水平呈负相关(P<0.05)。结论炎性因子均可作为急性脑梗死患者脑动脉狭窄的危险因素及标记物,与急性脑梗死患者脑动脉狭窄程度存在相关性,通过监测炎性因子水平,有助于评估病情程度及预后。

Objective To investigate the correlation between cerebral artery stenosis and inflammatory factors in patients with acute cerebral infarction .Methods 98 cases of acute cerebral infarction patients with cerebral artery stenosis , according to the degree of cerebral artery stenosis （TIMI classification） were divided into Ⅰ group of 29 cases, Ⅱ group of 41 patients and Ⅲ group of 28 pa-tients.42 healthy subjects were selected as control group .Comparison of carotid artery intima-media thickness （ IMT）, carotid artery distensibility, stiffness, plaque index,TNF-alpha,IL-6 and CRP levels.To analyze the correlation between the severity of cerebral ar-tery stenosis and inflammatory factors.Results The IMT, stiffness and plaque index, TNF-alpha,IL-6 and CRP levels in Ⅰ, Ⅱ, Ⅲ group were significantly higher than those in the control group , the expansion was significantly lower than that in the control group . There were significant differences among the three groups .Spearman correlation analysis showed that IMT , stiffness and plaque index were positively related with the levels of TNF-α、IL-6 and CRP.The expand index was negatively related with the levels of TNF-α、IL-6 and CRP.Conclusion Inflammatory factors can be used as the risk factors and marks of ischemic cerebral artery stenosis , they are re-lated to the degree of cerebral artery stenosis in patients with acute cerebral infarction .By monitoring the level of inflammatory factors , it is helpful to evaluate the severity and prognosis of the disease .