美洛西林联合阿奇霉素治疗小儿肺炎链球菌肺炎的临床疗效分析

Clinical efficacy analysis of mezlocillin combined with azithromycin in the treatment of infantile streptococcus pneumonia

目的探究美洛西林联合阿奇霉素治疗小儿肺炎链球菌肺炎的临床疗效。方法选取2015年1月至2016年1月我院诊治的肺炎链球菌肺炎患儿90例,按照随机数表法分为对照组和试验组各45例,对照组在常规治疗的基础上采用美洛西林治疗,试验组在对照组治疗的基础上联合阿奇霉素治疗,比较两组患儿的临床症状、临床疗效,评价治疗的安全性。结果试验组的退热时间、咳嗽咳痰消失时间、肺部啰音消失时间以及胸片恢复正常时间均明显短于对照组;治疗总有效率明显高于对照组,不良反应发生率明显低于对照组,差异均有统计学意义(P<0.05)。结论美洛西林联合阿奇霉素治疗小儿肺炎链球菌肺炎的临床疗效更好,且有更好的安全性,值得在今后的临床治疗中推广应用。

Objective To investigate the clinical effect of combination of mezlocillin and azithromycin in the treatment of in -fantile streptococcus pneumonia .Methods Ninety patients with infantile pneumonia from January 2015 to January 2016 in our hospital were selected .They were randomly divided into experimental or control group ,45 cases in each group .The control group received me-zlocillin treatment while the experimental group received combination of treatment of mezlocillin and azithromycin .Clinical symptoms , clinical efficacy and safety were compared between the two groups .Results Compared to the control group ,the pyretolysis time ,cough disappearance time ,pulmonary rales disappeared time and chest X-ray recovery time in the experimental group were shorter ,the total ef-fective rate was higher and the incidence of adverse reactions was less .All differences were statistically significant （ P 〈0.05 ） .Con-clusion Compared with mezlocillin alone ,combination treatment of mezlocillin and azithromycin may be more effective and safer to treat infantile pneumonia .