中国18岁及以上成年人自报牙龈出血与2型糖尿病患病相关性研究

Correlation between self-reported gingival bleeding and type 2 diabetes mellitus in aged ≥18 years adults in China

目的了解我国成年人自报经常牙龈出血与2型糖尿病（T2DM）患病相关性。方法利用2010年中国慢性病及其危险因素监测数据，描述性分析成年人中经常牙龈出血者的人口学及主要慢性疾病（糖尿病、高血压、血脂异常）患病情况，多因素分析经常牙龈出血与主要慢性疾病患病的相关性，进而分析年龄、高血压、血脂异常等因素与牙龈出血频率交互作用对T2DM患病的影响。结果93647名调查对象以汉族为主占87．4％（81872／93647），女性调查对象经常牙龈出血的比例高于男性，分别为63．6％（2020／3178）和36．4％（1158／3178）；经常牙龈出血人群中初中文化程度者所占比例最高为30．1％。在45～60岁人群中有12．8％（2839／22179）无牙龈出血但患T2DM，15．6％（163／1044）经常牙龈出血且患T2DM，经常牙龈出血与患T2DM相关（OR=1．29，95％CI：1．08～1．54，P〈0．005），年龄和经常牙龈出血对T2DM患病有交互作用（P〈0．005）；30316名男性无牙龈出血者中有3638例患T2DM，与之相比，经常牙龈出血者患T2DM（152／1143）的风险高1．30倍（95％CI：1．08～1．56，P=0．005）；在高血压人群中，与无牙龈出血者T2DM患病率（4817／26467）相比，经常牙龈出血者患T2DM的患病率高（21．1％，220／1043），OR=1．25（95％CI：1．07～1．46，P=0．006），且高血压和牙龈出血频率与T2DM患病有交互作用（P〈0．05）。结论经常牙龈出血与T2DM患病有相关性，且与年龄、患高血压有交互作用；男性并且经常牙龈出血同样与T2DM患病相关。

Objective To understand the correlation between self-reported gingival bleeding and type 2 diabetes meUitus （T2DM） in adults in China. Methods The database of China＇ s 2010 Chronic Disease and Risk Factor Surveillance （CCDRFS） survey among people aged ≥ 18 years was used to analyze the demographic characteristics of subjects with self-reporting gingival bleeding and the prevalence of major chronic diseases among adults. Correlation and interaction analyses were conducted on the relationships between frequent gingival bleeding and T2DM, hypertension and dyslipidemia, and interaction of age and gingival bleeding, age and hypertension, age and dyslipidemia, age and gender on the prevalence of T2DM. Results Among 93 647 adults surveyed, 87.4% were in Han ethnic group. The incidence of frequent gingival bleeding was higher in females （63.6%） than in males （36.4%）. The incidence of frequent gingival bleeding was highest （30.1%） in adults with middle school education level. Among the adults aged 45-60 years, 12.8%（2 839/22 179） had T2MD but no gingival bleeding, 15.6% （163/1 044） had both frequent gingival bleeding and T2DM, frequent gingival bleeding was correlated with T2DM （OR= 1.29, 95%CI： 1.08-1.54） and the interaction with age had influence on T2DM （P〈0.005）. In males, frequent gingival bleeding was correlated with T2DM （OR=l.30, 95% CI： 1.08-1.56, P=0.005）. In hypertension group, frequent gingival bleeding was correlated with T2DM （0R=1.25, 95% CI： 1.07-1.46）, and interaction of hypertension and gingival bleeding had influence on T2DM （P〈0.05）. Conclusions The positive correlation between frequent gingival bleeding and T2DM was observed in adults surveyed, and the interaction of age and hypertension had influence on prevalence of T2DM. Frequent gingival bleeding was correlated with T2DM in males either.