摘要
[目的]观察两性霉素B在体外对棘阿米巴生长的抑制作用.[方法]用生理盐水作为空白对照,甲硝唑2.0g/L作为阳性对照,观察1.0,5.0,10.0mg/L质量浓度的两性霉素B在体外作用8,24,48,72h时的棘阿米巴生长情况.[结果]质量浓度分别为5.0,10.0mg/L的两性霉素B作用24h时开始对棘阿米巴的生长具有抑制作用,而质量浓度为10.0mg/L的两性霉素B在体外对棘阿米巴生长的抑制作用明显优于甲硝唑.[结论]质量浓度为5.0mg/L以上的两性霉素B在体外对棘阿米巴具有抑制作用,且质量浓度为10.0mg/L时的抑制作用更为显著.
OBJECTIVETo observe the inhibitory effects of amphotericin B on the growth of Acanthamoeba in vitro.METHODS Using saline as a control and 2.0g/L metronidazole as a positive control,Acanthamoeba was cultured with 1.0,5.0,10.0mg/L concentration of amphotericin B in vitro.The growth status of Acanthamoeba was observed at 8,24,48 and 72hafter the first dose.RESULTS Amphotericin B with the concentration of 5.0and 10.0mg/L could inhibit the growth of Acanthamoeba at 24h（P〈0.05）.The inhibitory effect of 10.0mg/L amphotericin B at 24 hwas superior to metronidazole.CONCLUSION More than 5.0mg/L amphotericin B had inhibitory effect on the growth of Acanthamoeba in vitro,and the inhibitory effect of 10.0mg/L amphotericin B was more significant.
作者
刘斐
李红花
崔春权
金松竹
郑善子
LIU Fei LI Honghua CUI Chunquan JIN Songzu ZHENG Shanzi(Department of Immunology and Pathogenic Biology, Yanbian University College of Medicine, Yanji 133002, Jilin, China Tonghua Psychiatric Hospital, Tonghua 134000, Jilin , China)
出处
《延边大学医学学报》
CAS
2016年第4期264-266,共3页
Journal of Medical Science Yanbian University
