低频重复经颅磁刺激治疗轻中度抑郁症睡眠障碍效果

LOW-FREQUENCY REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION:ITS EFFECT ON MILD-TO-MODERATE DEPRESSION SLEEP DISORDER

目的探讨低频重复经颅磁刺激治疗轻中度抑郁症病人睡眠障碍的效果。方法收集40例首发抑郁症病人,汉密尔顿抑郁量表评分均≥17分而〈24分;将病人随机分为两组,每组20例。两组病人均给予草酸艾司西酞普兰治疗,研究组病人联合应用低频重复经颅磁刺激治疗,对照组病人联合应用伪经颅磁刺激治疗,共治疗4周。分别于治疗前后应用匹兹堡睡眠质量指数（PSQI）评估两组病人睡眠情况并进行比较。结果治疗后两组病人PSQI总分及各因子分均较治疗前降低,差异有统计学意义（t=2.08-3.14,P〈0.05）。治疗前两组病人PSQI总分及各因子分比较差异无显著性（P〉0.05）;治疗后研究组病人PSQI总分和睡眠紊乱得分较对照组病人低,差异有统计学意义性（t=2.80、3.68,P〈0.05）。结论低频重复经颅磁刺激对于改善轻中度抑郁症病人的睡眠障碍有一定作用。

Objective To assess the effect of low-frequency repetitive transcranial magnetic stimulation （LFRTMS） on sleep disorder in patients with mild-to-moderate depression. Methods Forty patients with first episode depression- Hamilton Depression Scale scores 17-24 points- were selected. The patients were divided into two groups in random with 20 in each group. Patients in both groups were treated with eseitalopram citalopram, and LFRTMS was added to those in the research group, for those in the control group, pseudo LFRTMS was given. A total treatment was four weeks. Employing Pittsburgh sleep quality index （PSQI）, sleep quality of patients in the two groups was evaluated and compared--before and after therapy. Results After treatment, the PSQI total score of the two groups and each factor score were lower than that before treatment, the difference was significant （t = 2.08-3.14,P%0.05）. Before treatment, the differences in PSQI total score and each factor score between the two groups were not significant （P〉0.05）, after treatment, the PSQI total score and sleep disorder score were lower in the research group versus the control group （t=2.80,3.68,P〈0.05）. Conclusion Low--frequency repetitive transcranial magnetic stimula- tion has a certain effect on improving sleep disorder in patients with mild to moderate depression.