分泌蛋白质组学在肿瘤标志物中的研究进展

Research Progress on Tumor Markers by Secretomics

在肿瘤发生、发展过程中,肿瘤细胞会分泌出大量蛋白质,而一些分泌蛋白已作为肿瘤标志物被用于肿瘤的临床检测与预后判断。随着蛋白质组学技术的快速发展,分泌蛋白质组学应运而生,并为肿瘤研究提供了新的思路与方法。现就分泌蛋白质组学在肿瘤标志物研究中的策略及进展做一综述,旨在为研究人员在肿瘤标志物发现及筛选方面提供借鉴。

In the occurrence and development processes of tumor, a large number of proteins are secreted by tumor cells, and some of them are considered as tumor markers and used for clinical detection and prognosis. With the rapid development of proteomics techniques, secretomics is born at the right moment and provides new ideas and methods for tumor research. Now the strategy and the advance in the study of tumor markers by secretomics are reviewed, which may provide reference for the researchers in the discovery and screening of tumor markers.