针挑治疗对精索静脉曲张不育患者血液流变指标及疗效的影响

Effect of Needle Pricking Therapy on Rheological Indices and Efficacy for Infertile Patients with Varicocele

目的观察针挑治疗对精索静脉曲张(varicocele,VC)不育患者血液流变指标及疗效的影响。方法采用随机数字表法将215例男性VC不育症患者分成治疗组(针挑组,109例)与对照组(药物组,106例),治疗组采用陈氏挑针疗法治疗,每周1次,共10次;对照组口服桂枝茯苓胶囊治疗,0.31 g/粒,每次3粒,每日3次,连服70天。治疗75天后检测两组精索静脉管径、全血表观黏度及血浆黏度值;测定精子计数、精子活率、精子活力及精子畸形率等精子参数评价疗效,并在治疗前后行血、尿、便常规,肝、肾功能检查评价安全性。结果与本组治疗前比较,治疗后两组Ⅰ度、Ⅱ度VC患者精索静脉管径均缩窄(P<0.05),且治疗组Ⅱ度患者精索静脉管径较对照组缩窄更明显(P<0.01)。与本组治疗前比较,两组治疗后精液质量均改善(P<0.05,P<0.01);且治疗组精子密度增加,精子活率增高,正常形态精子增多,液化时间缩短,均明显优于对照组(P<0.05)。与治疗前比较,治疗组治疗后全血表观黏度及血浆黏度值均明显下降(P<0.05)。治疗组总有效率明显优于对照组(P<0.05)。结论针挑治疗可明显改善VC不育患者精索静脉血流量及血管舒缩弹性,降低血流黏稠度,从而有助于促进血液循环和降低精索静脉曲张。

Objective To observe the effect of needle pricking therapy on theological indices and efficacy for infertile patients with varicocele （VC）. Methods A total of 215 infertility patients with VC were assigned to the treatment group （109 cases, treated by needle pricking therapy） and the control group （106 cases, treated by drug therapy）. Patients in the treatment group received CHEN＇s needle pricking therapy, once per week for a total of 10 times. Those in the control group took Guizhi Fuling Cap- sule （GFC）, O. 31g/pill, 3 pills each time, three times per day for 70 successive days. The diameter of VC, whole blood apparent viscosity, and plasma viscosity value were detected in the two groups after 75- day treatment. Sperm count, sperm motility rate, sperm motility, teratopermia rate, and other parameters were determined to evaluate the efficacy. Routines of blood, urine, and stool were detected. Renal and liver functions were examined to evaluate the safety. Results Compared with before treatment in the same group, the diameter of VC was narrowed in gradeⅠ and 11 patients of the two groups after treatment （P 〈0.05）. The diameter of VC was obviously narrower in grade Ⅱ patients of the treatment group after treatment （P 〈0.01 ）. Compared with before treatment in the same group, semen quality was improved in the two groups after treatment （P 〈0.05,P 〈0.01 ）. Besides, sperm density was reduced, sperm motility rate was elevated, spermatozoa with normal morphology was increased with longer fluid- ized time in the treatment group after treatment, which were all better than those of the control group （P 〈0.05）. Compared with before treatment, whole blood apparent viscosity and plasma viscosity value both obviously decreased in the treatment group after treatment （P 〈0.05）. The total effective rate was better in the treatment group than in the control group （P 〈0.05）. Conclusion Needle pricking therapy could obviously improve blood flow and vasomotic elasticity of infertile patients with VC, lower plasma viscosity, thus promoting blood circulation and lowering VC.