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探讨长期酒精暴露对视网膜的损伤

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摘要 目的探讨患者长期酒精暴露对视网膜的损伤。方法选取野生型(wild type,WT)小鼠27只,酒精暴露建立动物模型,利用荧光抗体染色法观察视网膜胶质细胞的变化。结果长期酒精暴露后,小鼠视网膜胶质细胞出现损伤,如Müller细胞GS染色减弱、星形胶质细胞数量减少,并且呈剂量依赖性(P<0.05)。结论长期酒精暴露可通过改变视网膜的胶质细胞Müller细胞和星形胶质细胞的数量和形态对视网膜造成损伤,且呈剂量依赖性。
出处 《中国实用神经疾病杂志》 2016年第18期67-69,共3页 Chinese Journal of Practical Nervous Diseases
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