稳心颗粒联合丁螺环酮治疗伴有ST-T改变的心脏神经症患者的疗效观察

Observation of curative effect of Wenxinkeli combined with buspirone on patients with cardiac neurosis associated with ST-T changes

目的观察稳心颗粒联合丁螺环酮治疗伴有ST-T改变的心脏神经症的疗效。方法收集明确诊断为心脏神经症的患者90例,采用随机分组法分为安慰剂组、稳心颗粒组、联合组(稳心颗粒联合丁螺环酮),每组均30例。观察服药4周末和8周末,3组患者的汉密尔顿焦虑量表(HAMA-14)和汉密尔顿抑郁量表(HAMD-24)的得分,以及稳心颗粒联合丁螺环酮治疗12个月后的患者SF-36量表得分和ST-T改善情况。结果经治疗4周后联合组、稳心颗粒组和安慰剂组的HAMA-14和HAMD-24得分明显低于治疗前(P<0.05);但第8周末比较显示,联合组HAMA-14和HAMD-24得分显著低于稳心颗粒组与安慰剂组,组间差异有统计学意义(P<0.05)。3组患者随访12个月后的SF-36得分显示联合组患者的得分明显高于治疗前及其他两组(P<0.05)。联合组患者随访结果显示第8周末和第12月末的ST-T改善有效率均显著高于治疗前及其他两组(P<0.05)。结论稳心颗粒联合丁螺环酮治疗心脏神经症显著改善患者的焦虑及抑郁情绪,长期治疗能明显提高患者的生活质量并改善ST-T改变的躯体症状。

Objective To observe the effects of Wenxinkeli combination use with buspirone on the treatment of car- diac neurosis with ST-T changes. Methods Ninety patients with cardiac neuropathy were randomly divided into placebo group, Wenxin Granule group and combination use group （Wenxinkeli combination use with buspirone） , 30 cases in each group. The scores of HAMA-14 and HAMD-24 of the three groups were observed at the end of 4 and 8 weeks after treatment when the score of SF-36 and the improvement of ST-T of combination use group were e- valuated followed 12 weeks treatment. Results After 4 weeks of treatment, the two scale scores of combination use group and the Wenxinkeli group, including HAMD-24 and HAMA-14, were significantly lower than the placebo group （P 〈 O. 05 ）. In comparison with placebo group, the scores of HAMD-24 and the HAMA-14 were significant- ly lower after 8 weeks treatment. After 12 months of follow-up treatment, the SF-36 scores of combination use group were significantly higher than the other two groups＇ （ P 〈 0. 05 ）. Meanwhile, our results showed that the ST-T changes of the combination use group was significantly improved than the other two groups＇ （ P 〈 0. 05 ）. Conclu- sion The treatment of Wenxinkeli combination use with buspirone can significantly decrease anxiety and improve depression in patients with cardiac neurosis, moreover, long-term combination use treatment can distinctly improve patients＇ quality of life and relieve their physical symptoms of ST-T changes.