EB病毒感染T淋巴细胞增殖1例并文献复习

Epstein-Barr Virus Infection Associated T Lymphoproliferative Disease： A Case Report and Review of the Literatures

目的分析Epstein-Barr病毒（EB病毒）感染T淋巴细胞组织增殖伴噬血细胞综合征患者的临床特征。方法回顾性分析2016年收治1例EB病毒感染T淋巴细胞组织增殖伴噬血细胞综合征患者的临床表现、实验室检查、治疗方案及临床转归，并复习相关文献。结果该患者经实验室检查确诊，期间给予抗病毒、抗感染、营养支持等对症处理，后因个人原因未行免疫治疗或化疗，自行出院。结论EB病毒感染T淋巴细胞组织增殖伴噬血细胞综合征患者临床表现多样，治疗方案有依托泊苷联合糖皮质激素和环孢素等，并可进行造血干细胞移植。但病情进展快速，病死率高，预后欠佳。

Objective To analyze the clinical characteristics of Epstein-Barr virus T Lymphoproliferative associated with hemophagocytic lymphohistiocytosis. Methods A retrospective investigation of the clinical manifestation, laboratory test and clinical course of 1 case with Epstein-Barr virus T Lymphoproliferative associated hemophagocytic lymphohistiocytosis in 2016 was done with relevant literature review. Result The diagnosis of the patient hospitalized in the Department of Hematology confirmed by laboratory tests. The patient was given antiviral, antiinfection, nutritional support and symptomatic treatment, without immunotherapy or chemotherapy due to personal reasons. Conclusion Epstein-Barr virus T Lymphoproliferative associated hemophagocytic lymphohistiocytosis is a rapidly progressive disease with a high rate of mortality. The combination of dexamethasone, etoposide and cyclosporin A is one choice of the treatment, and hematopoietic stem cell transplantation can be done.