北京某社区不同性别老年人群血尿酸水平与高血压的现况研究

Cross-sectional study on the association between serum uric acid level and hypertension by gender in the elderly population of a district in Beijing

目的在社区老年人群中,探讨血尿酸(serum uric acid,SUA)水平与高血压的关系。方法在2009年9月~2010年6月期间,使用整群随机抽样的方法对北京市万寿路地区60岁及以上的老年人进行横断面调查。结果本研究的分析样本为2 074例老年人(男性839例,女性1 235例)。在老年女性的研究对象中,血尿酸水平的增加使高血压的患病风险增加(OR=1.004,95%CI:1.002~1.006,P<0.001);以血尿酸四分位数最低组作为参照组,随着血尿酸水平增加,高血压的患病风险增加(血尿酸水平Q2(OR=1.263,95%CI:0.902~1.773,P=0.187),血尿酸水平Q3(OR=2.008,95%CI:1.412~2.872,P<0.001)和血尿酸水平Q4(OR=2.015,95%CI:1.403~2.922,P<0.001));患有高尿酸血症者,罹患高血压的风险高于非高尿酸血症者(OR=1.563,95%CI:1.082~2.253,P=0.018)。在男性中,仅血尿酸水平使高血压的患病风险增加(OR=1.002,95%CI:1.000~1.004,P=0.036)。结论血尿酸水平与高血压有相关性,特别是在老年女性当中。临床医生应特别关注老年女性的血尿酸水平,维持正常的血尿酸水平可能对高血压的预防和控制具有重要作用。

Objective To evaluate the association between the serum uric acid （SUA） level and the prevalence of hypertension in community elderly population. Methods A population-based cross-sectional study was conducted in Wanshoulu area of Beijing, China. Results A total of 2 074 community elderly （839 males and 1 235 females） participants aged≥60 years were included in the analysis. In female participants, the adjusted odds ratio （OR） and its corresponding 95% confidence interval of having hypertension was （ OR = 1. 004,95% CI： 1. 002-1. 006, P 〈0. 001 ） for each 1 μmol/L increase in the SUA level after multiple adjustments. Compared to Q1, the OR adjusted （95% CI） of the Q2 vs. QI, Q3 vs. Q1 and Q4 vs. Q1 SUA quartiles for hypertension were （ OR = 1. 263,95% CI：0. 902-1. 773, P = 0. 187）, （ OR = 2. 008,95% CI： 1. 412-2. 872, P 〈 0. 001 ）, （ OR = 2. 015,95% CI： 1. 403-2. 922, P 〈 0. 001 ）, respectively. The adjusted OR （95% CI） of hyperuricemia for hypertension was （OR = 1. 563,95% CI：I. 082-2. 253, P =0. 018）. In males, the adjusted OR （95% CI） of having hypertension was （ OR = 1. 002,95% CI：i. 000-1. 004 P =0. 036） for each 1 μmol/L increase in the SUA level. Conclusions There is a correlation between SUA level and hypertension, especially in the eld- erly women. Clinicians should pay special attention to SUA level of elderly women. Maintaining the normal level of SUA may play an important role in hypertension prevention and control.